外源性左旋肉碱对高脂饮食诱导的大鼠高脂血症的影响。

The effect of exogenous L-carnitine on fat diet-induced hyperlipidemia in the rat.

作者信息

Maccari F, Pessotto P, Ramacci M T, Angelucci L

出版信息

Life Sci. 1985 May 20;36(20):1967-75. doi: 10.1016/0024-3205(85)90446-1.

Abstract

In rats receiving a fat diet (75% Altromin R and 25% olive oil) ad libitum for 15 hours, an orally administered dose of 500 mg/kg L-carnitine produces: an increase in serum carnitine and acetyl-carnitine levels; a decrease in serum triglyceride (TG) and free fatty acid (FFA) levels; a normalization of the heart and liver carnitine pattern; a reduction of myocardial neutral lipase (NL) activity, without affecting lipoprotein lipase (LPL) of the heart. Under these experimentally-induced conditions, L-carnitine stimulates the excretion of acyl groups as acyl-carnitines with the urine. Acylcarnitines are practically absent from the urine of control animals.

摘要

在大鼠随意摄入高脂饮食（75%爱宝美R饲料和25%橄榄油）15小时后，口服500毫克/千克的左旋肉碱会产生以下效果：血清肉碱和乙酰肉碱水平升高；血清甘油三酯（TG）和游离脂肪酸（FFA）水平降低；心脏和肝脏肉碱模式恢复正常；心肌中性脂肪酶（NL）活性降低，而不影响心脏的脂蛋白脂肪酶（LPL）。在这些实验诱导的条件下，左旋肉碱会刺激酰基以酰基肉碱的形式随尿液排出。对照动物的尿液中几乎不存在酰基肉碱。