Dahar Maria M, Both MacKenzie, Lord Linda M, Densmore Carly, Saubermann Lawrence J
Carondelet St. Joseph's Hospital, Tucson, AZ, USA.
Division of Gastroenterology, Hepatology and Endoscopy, University of Rochester Medical Center, Rochester, NY, USA.
Case Rep Gastroenterol. 2025 Feb 4;19(1):57-61. doi: 10.1159/000543291. eCollection 2025 Jan-Dec.
Patients with short bowel syndrome (SBS) on conventional oral diets often face nutritional deficiencies and dehydration, a challenge further compounded during pregnancy. This case report describes the use of a glucagon-like peptide-2 (GLP-2) analog in the nutritional management of an SBS patient dependent on total parenteral nutrition (TPN).
A 29-year-old woman with a significant medical history of Crohn's disease leading to SBS was traditionally dependent on TPN for sustenance. During her pregnancy, she was successfully managed with a GLP-2 analog, which enabled her to wean off TPN. This successful management underscores the therapeutic potential of GLP-2 analogs in effectively altering the nutritional landscape for SBS patients, including during the physiologically demanding period of pregnancy.
GLP-2 analogs helped with the nutritional management of patients with SBS during pregnancy and helped them wean off TPN. There is a need for further research and exploration into GLP-2 analogs as viable alternatives to conventional treatments such as TPN in the care and management of SBS patients during pregnancy.
患有短肠综合征（SBS）的患者在采用传统口服饮食时常常面临营养缺乏和脱水问题，而在孕期这一挑战会更加复杂。本病例报告描述了一种胰高血糖素样肽-2（GLP-2）类似物在一名依赖全胃肠外营养（TPN）的SBS患者营养管理中的应用。
一名29岁女性，有因克罗恩病导致SBS的重大病史，传统上依赖TPN维持生命。在她怀孕期间，使用GLP-2类似物成功进行了管理，使其能够停用TPN。这一成功管理突出了GLP-2类似物在有效改变SBS患者营养状况方面的治疗潜力，包括在生理需求较高的孕期。
GLP-2类似物有助于孕期SBS患者的营养管理，并帮助他们停用TPN。有必要进一步研究和探索GLP-2类似物，作为在孕期SBS患者护理和管理中替代TPN等传统治疗方法的可行选择。
