Vijayalakshmi R, Ambalavanan N, Rajeshkumar S, Mahendra Jaideep, Sudhakar Uma, Parameswari Devi
Dept of Periodontology, Meenakshi Ammal Dental College & Hospital, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Maduravoyal, Chennai, India.
Nanobiomedicine Lab, Saveetha Dental College & Hospital, SIMATS, Saveetha University, Chennai, India.
J Oral Biol Craniofac Res. 2025 Jan-Feb;15(1):199-204. doi: 10.1016/j.jobcr.2024.12.011. Epub 2025 Jan 21.
This study compared the drug release kinetics of mediated selenium nanoparticles (SeNPs) gel and zinc oxide nanoparticles (ZnONPs) gel for their potential in local drug delivery for chronic periodontitis.
The drug release was evaluated in-vitro by conducting tests on different formulations, including 1 %, 2 %, 3 %, 4 %, and 5 % mediated SeNPs gel and ZnONPs gel. Each sample, approximately 0.1 mg, was mixed with 10 mL of phosphate buffer saline (PBS) at various pH levels and maintained at 37 °C. The suspension was then placed in an incubated shaker at 120 rpm for 1 h. Five-milliliter samples were withdrawn from the dissolution medium at 30-min intervals and replaced with fresh PBS buffer to maintain a constant volume. The released drug amount was measured using a UV spectrophotometer (Systronics, India) at 290 nm.
The investigation revealed that SeNPs gel exhibited higher drug release percentages compared to ZnONPs gel across various concentrations and time points. The sustained release profiles of both formulations suggest effective control over drug release, maintaining therapeutic drug levels over an extended period. The near-complete release of the drug at 500 min highlights the potential for prolonged therapeutic efficacy, reducing the need for frequent dosing and enhancing patient compliance.
mediated SeNPs gel shows promise for more rapid and sustained drug delivery in the management of chronic periodontitis through local drug delivery systems.
本研究比较了介孔硒纳米颗粒（SeNPs）凝胶和氧化锌纳米颗粒（ZnONPs）凝胶的药物释放动力学，以评估它们在慢性牙周炎局部给药中的潜力。
通过对不同配方进行测试来体外评估药物释放，这些配方包括1%、2%、3%、4%和5%的介孔SeNPs凝胶和ZnONPs凝胶。每个约0.1毫克的样品在不同pH值下与10毫升磷酸盐缓冲盐水（PBS）混合，并保持在37°C。然后将悬浮液置于恒温振荡器中，以120转/分钟振荡1小时。每隔30分钟从溶解介质中取出5毫升样品，并用新鲜的PBS缓冲液替换，以保持体积恒定。使用紫外分光光度计（印度 Systronics）在290纳米处测量释放的药物量。
研究表明，在各种浓度和时间点下，SeNPs凝胶的药物释放百分比均高于ZnONPs凝胶。两种配方的缓释曲线表明对药物释放有有效控制，能在较长时间内维持治疗药物水平。在500分钟时药物接近完全释放，这突出了延长治疗效果的潜力，减少了频繁给药的需求并提高了患者的依从性。
介孔SeNPs凝胶有望通过局部给药系统在慢性牙周炎的治疗中实现更快速和持续的药物递送。
