Yilmaz Seval, Ünlüer Nezehat Özgül
Department of Physical Therapy and Rehabilitation, School of Health Sciences, Atılım University, Ankara, Turkey.
Gülhane Faculty of Physiotherapy and Rehabilitation, Sağlık Bilimleri Health Sciences University, Ankara, Turkey.
Neurol Res. 2025 Mar;47(3):188-194. doi: 10.1080/01616412.2025.2462734. Epub 2025 Feb 5.
Multiple sclerosis (MS) affects muscle strength and postural stability. However, the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS is not well known. The aim of the study was to examine the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS patients.
The study included 21 mild-stage MS patients with an EDSS score of 4 or less and 21 healthy controls. The concentric and isometric strength of knee flexors and extensors was measured with the Biodex System 4 Dynamometer, and postural stability with the Biodex Balance System under eyes-open and eyes-closed conditions on a rigid surface.
Mild-stage MS patients had reduced concentric strength of knee extensors and flexors and increased postural sway compared with healthy controls ( < 0.05). Isometric strength of knee extensors and flexors in mild stage MS patients were similar to healthy controls ( > 0.05). There was a moderate positive correlation between concentric strength of knee extensors and flexors and isometric strength of knee flexors and open-eye postural stability indexes in mild stage multiple sclerosis patients ( < 0.05).
While isometric strength of knee extensors and flexors was preserved, concentric strength of knee extensors and flexors was decreased, and postural stability was adversely affected in mild stage MS patients. The increase in the strength of the knee muscles was associated with an increase in their postural sway in mild stage MS patients.
多发性硬化症（MS）会影响肌肉力量和姿势稳定性。然而，轻度多发性硬化症患者膝关节屈伸肌的向心收缩力量和等长收缩力量与姿势稳定性之间的关系尚不清楚。本研究的目的是探讨轻度多发性硬化症患者膝关节屈伸肌的向心收缩力量和等长收缩力量与姿势稳定性之间的关系。
本研究纳入了21例扩展残疾状态量表（EDSS）评分为4分及以下的轻度多发性硬化症患者和21名健康对照者。使用Biodex System 4测力计测量膝关节屈伸肌的向心收缩力量和等长收缩力量，并在刚性表面上，于睁眼和闭眼条件下使用Biodex平衡系统测量姿势稳定性。
与健康对照者相比，轻度多发性硬化症患者膝关节伸肌和屈肌的向心收缩力量降低，姿势摆动增加（P<0.05）。轻度多发性硬化症患者膝关节伸肌和屈肌的等长收缩力量与健康对照者相似（P>0.05）。在轻度多发性硬化症患者中，膝关节伸肌和屈肌的向心收缩力量与膝关节屈肌的等长收缩力量及睁眼姿势稳定性指标之间存在中度正相关（P<0.05）。
在轻度多发性硬化症患者中，虽然膝关节伸肌和屈肌的等长收缩力量得以保留，但膝关节伸肌和屈肌的向心收缩力量下降，姿势稳定性受到不利影响。在轻度多发性硬化症患者中，膝关节肌肉力量的增加与姿势摆动的增加有关。
