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High Baseline High-Sensitivity Cardiac Troponin T Concentrations and Risk of Index Acute Myocardial Infarction.高基线高敏心肌肌钙蛋白 T 浓度与指数急性心肌梗死风险。
Mayo Clin Proc. 2024 Sep;99(9):1435-1442. doi: 10.1016/j.mayocp.2023.12.019. Epub 2024 Mar 16.
2
Pre-hospital rule-out of non-ST-segment elevation acute coronary syndrome by a single troponin: final one-year outcomes of the ARTICA randomised trial.通过单次肌钙蛋白检测在院前排除非ST段抬高型急性冠状动脉综合征：ARTICA随机试验的一年最终结果
Eur Heart J Qual Care Clin Outcomes. 2024 Aug 8;10(5):411-420. doi: 10.1093/ehjqcco/qcae004.
3
2023 ESC Guidelines for the management of acute coronary syndromes.2023年欧洲心脏病学会急性冠状动脉综合征管理指南。
Eur Heart J. 2023 Oct 12;44(38):3720-3826. doi: 10.1093/eurheartj/ehad191.
4
Use of the HEAR Score for 30-Day Risk-Stratification in Emergency Department Patients.HEAR 评分在急诊科患者 30 天风险分层中的应用。
Am J Med. 2023 Sep;136(9):918-926.e5. doi: 10.1016/j.amjmed.2023.04.041. Epub 2023 May 24.
5
Implementation of High-Sensitivity Cardiac Troponin Assays in the United States.美国高敏心肌肌钙蛋白检测的应用。
J Am Coll Cardiol. 2023 Jan 24;81(3):207-219. doi: 10.1016/j.jacc.2022.10.017. Epub 2022 Oct 31.
6
2022 ACC Expert Consensus Decision Pathway on the Evaluation and Disposition of Acute Chest Pain in the Emergency Department: A Report of the American College of Cardiology Solution Set Oversight Committee.2022年美国心脏病学会急诊室急性胸痛评估与处置专家共识决策路径：美国心脏病学会解决方案集监督委员会报告
J Am Coll Cardiol. 2022 Nov 15;80(20):1925-1960. doi: 10.1016/j.jacc.2022.08.750. Epub 2022 Oct 11.
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Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers.导出高敏心肌肌钙蛋白检测 99 百分位上限参考值的分析考虑因素：国际临床化学和检验医学联合会心脏生物标志物临床应用委员会的教育建议。
Clin Chem. 2022 Jul 27;68(8):1022-1030. doi: 10.1093/clinchem/hvac092.
8
Rapid Exclusion of Acute Myocardial Injury and Infarction With a Single High-Sensitivity Cardiac Troponin T in the Emergency Department: A Multicenter United States Evaluation.在急诊科应用单次高敏心肌肌钙蛋白 T 快速排除急性心肌损伤和梗死：一项多中心美国评估。
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Outcomes Associated with Introduction of the 5 Generation High-Sensitivity Cardiac Troponin in Patients Presenting with Cardiovascular Disorders.与心血管疾病患者中引入第 5 代高敏心肌肌钙蛋白相关的结果。
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Association between delays to patient admission from the emergency department and all-cause 30-day mortality.从急诊科入院到患者死亡的时间延迟与全因 30 天死亡率之间的关联。
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高敏心肌肌钙蛋白检测：从实施到资源利用及成本效益

High-Sensitivity Cardiac Troponin Assays: From Implementation to Resource Utilization and Cost Effectiveness.

作者信息

Lee Hong-Kee, McCarthy Cian P, Jaffe Allan S, Body Richard, Alotaibi Ahmed, Sandoval Yader, Januzzi James L

机构信息

Department of Pathology and Laboratory Medicine, Endeavor Health, Evanston, IL, United States.

Department of Pathology, University of Chicago Pritzker School of Medicine, Chicago, IL, United States.

出版信息

J Appl Lab Med. 2025 May 2;10(3):710-730. doi: 10.1093/jalm/jfae161.

DOI:10.1093/jalm/jfae161
PMID:39907688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12068378/
Abstract

BACKGROUND

Cardiac troponin is the gold-standard biomarker for the evaluation of patients with suspected acute myocardial infarction (MI). Improvements in assay technology have led to high-sensitivity cardiac troponin assays that, when incorporated into accelerated diagnostic pathways, may rapidly diagnose or exclude acute MI more efficiently than conventional troponin assays.

CONTENT

In this narrative review, we provide practical suggestions for implementing high-sensitivity cardiac troponin assays, review accelerated diagnostic pathways incorporating these assays, and review the impact of these assays on resource utilization and cost-effectiveness in relation to the evaluation of individuals with possible acute MI.

SUMMARY

An increasing number of hospitals are transitioning to high-sensitivity cardiac troponin assays. This narrative review provides an overview of the potential benefits of this transition.

摘要

背景

心肌肌钙蛋白是评估疑似急性心肌梗死（MI）患者的金标准生物标志物。检测技术的改进催生了高灵敏度心肌肌钙蛋白检测方法，将其纳入加速诊断流程后，可能比传统肌钙蛋白检测方法更高效地快速诊断或排除急性心肌梗死。

内容

在本叙述性综述中，我们为实施高灵敏度心肌肌钙蛋白检测提供实用建议，回顾纳入这些检测方法的加速诊断流程，并探讨这些检测方法在评估可能患有急性心肌梗死的个体时对资源利用和成本效益的影响。

总结

越来越多的医院正在转向高灵敏度心肌肌钙蛋白检测。本叙述性综述概述了这一转变的潜在益处。