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十年的过渡性疼痛服务研究与实践:我们现状如何,未来又将何去何从?

Ten years of transitional pain service research and practice: where are we and where do we go from here?

作者信息

Clarke Hance, Waisman Anna, Aternali Andrea, Axenova Kristina, Almohawis Amjaad, Curtis Kathryn, Fiorellino Joseph, Flynn Michelle, Ganty Praveen, Huang Alexander, Hong Zhaorong, Katznelson Rita, Kotteeswaran Yuvaraj, Ladak Salima, Ladha Karim S, Lomanowska Anna, Lumsden-Ruegg Heather, Mahamid Ala, McCarthy Molly, Miles Sarah, Nicholls Judith, Pagé M Gabrielle, Peer Miki, Rosenbloom Brittany N, Santa Mina Daniel, Siegal Rachel, Slepian P Maxwell, Sutherland Ainsley, Tamir Diana, Tao Leeping, Tumber Paul, Wieskopf Jeffrey, Williams Callon, Woodford Elizabeth, Katz Joel

机构信息

Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada

Transitional Pain Service, Toronto General Hospital, Toronto, Ontario, Canada.

出版信息

Reg Anesth Pain Med. 2025 Feb 5;50(2):188-203. doi: 10.1136/rapm-2024-105609.

Abstract

Chronic postsurgical pain (CPSP) is a prevalent yet unintended consequence of surgery with substantial burdens to the individual and their family, the healthcare system, and society at large. The present article briefly reviews the evidence for transitional pain services (TPSs) that have arisen in an effort to prevent and mange CPSP and persistent opioid use, and provides an update on recent novel risk factors for CPSP. Available evidence from one randomized controlled trial (RCT) and three non-randomized cohort studies suggests that TPS treatment is associated with better opioid use outcomes, including fewer opioid tablets prescribed at discharge, better opioid weaning results, a lower incidence of new-onset chronic opioid use, and lower consumption of opioids even at later time points up to 1 year after surgery. Another RCT indicates TPS treatment can be enhanced by provision of perioperative clinical hypnosis. While these preliminary studies are generally positive, large-scale, RCTs are needed to provide a more definitive picture of whether TPSs are effective in reducing opioid consumption and improving pain and mental health outcomes in the short and long term. With the expansion of TPSs across North America and globally, perioperative care focused on reducing the transition to pain chronicity has the potential to help millions of patients. With additional evidence from well-controlled RCTs, TPSs are well poised to continue to evolve and strengthen the role of multidisciplinary care teams in the immediate postdischarge period and beyond.

摘要

慢性术后疼痛(CPSP)是手术常见但意外的后果,给患者及其家庭、医疗保健系统以及整个社会带来了沉重负担。本文简要回顾了为预防和管理CPSP及持续使用阿片类药物而出现的过渡性疼痛服务(TPS)的相关证据,并介绍了CPSP近期新出现的危险因素。一项随机对照试验(RCT)和三项非随机队列研究的现有证据表明,TPS治疗与更好的阿片类药物使用结果相关,包括出院时开具的阿片类药片数量减少、阿片类药物戒断效果更好、新发慢性阿片类药物使用的发生率更低,甚至在术后长达1年的后期时间点阿片类药物的消耗量也更低。另一项RCT表明,围手术期临床催眠可增强TPS治疗效果。虽然这些初步研究总体上是积极的,但仍需要大规模的RCT来更明确地了解TPS在短期和长期内是否能有效减少阿片类药物的消耗并改善疼痛和心理健康结果。随着TPS在北美和全球的扩展,专注于减少向慢性疼痛转变的围手术期护理有潜力帮助数百万患者。有了来自严格对照RCT的更多证据,TPS有望继续发展并加强多学科护理团队在出院后及更长时间的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/11877109/7f66e3233871/rapm-50-2-g001.jpg

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