Le Hai, Fenchel Daphna, Dimitrakopoulou Konstantina, Patel Hamel, Curtis Charles, Cordero-Grande Lucilio, Edwards A David, Hajnal Joseph, Tournier Jacques-Donald, Deprez Maria, Cullen Harriet
Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Translational Bioinformatics Platform, NIHR Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust and King's College London, London, UK.
Transl Psychiatry. 2025 Feb 5;15(1):41. doi: 10.1038/s41398-025-03253-2.
Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD polygenic risk score (PRS) and volumes of the frontal, temporal, parietal, occipital, fronto-temporal and parieto-occipital lobes in 273 term-born infants of European ancestry in the developing Human Connectome Project. ASD PRS was positively associated with frontal (β = 0.027, p = 0.04) and fronto-temporal (β = 0.024, p = 0.01) volumes, but negatively with parietal (β = -0.037, p = 0.04) and parieto-occipital (β = -0.033, p = 0.01) volumes. This preliminary result suggests the potential involvement of ASD common genetic variants in early structural variations linked to ASD.
Arch Gen Psychiatry. 2011-5
Front Neurosci. 2022-5-23
J Integr Neurosci. 2022-3-22
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