Park Sung Keun, Oh Chang-Mo, Ryoo Jae-Hong, Jung Ju Young
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Sci Rep. 2025 Feb 5;15(1):4411. doi: 10.1038/s41598-025-88787-7.
We aimed to examine the effects of sodium and potassium intake on the risk of diabetes mellitus (DM). In a cohort of 99,552 working-age Korean adults (60,591 men; mean age 39.7 ± 6.9 and 38,961 women; mean age 38.4 ± 6.5), we longitudinally evaluated the risk of DM in relation to quartile levels of sodium intake, potassium intake, and the sodium-potassium ratio. A Cox proportional hazards model was used to assess the risk of DM by calculating adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident DM (adjusted HR [95% CI]). In men, sodium intake was not associated with the risk of DM (first quartile: reference, second quartile: 0.96 [0.87-1.07], third quartile: 0.94 [0.84-1.05], and fourth quartile: 1.02 [0.89-1.18]). Women did not show a significant association between sodium intake and the risk of DM (first quartile: reference, second quartile: 0.87 [0.69-1.09], third quartile: 1.02 [0.81-1.29], and fourth quartile: 1.01 [0.76-1.33]). Additionally, potassium intake and the sodium-potassium ratio were not significantly associated with the risk of DM in either men or women. In conclusion, no significant association was observed between sodium or potassium intake and the risk of DM among working-age Korean adults.
我们旨在研究钠和钾的摄入量对糖尿病（DM）风险的影响。在一个由99,552名工作年龄的韩国成年人组成的队列中（男性60,591名；平均年龄39.7±6.9岁，女性38,961名；平均年龄38.4±6.5岁），我们纵向评估了与钠摄入量、钾摄入量以及钠钾比的四分位数水平相关的糖尿病风险。采用Cox比例风险模型，通过计算新发糖尿病的校正风险比（HRs）和95%置信区间（CIs）来评估糖尿病风险（校正HR [95% CI]）。在男性中，钠摄入量与糖尿病风险无关（第一四分位数：参照，第二四分位数：0.96 [0.87 - 1.07]，第三四分位数：0.94 [0.84 - 1.05]，第四四分位数：1.02 [0.89 - 1.18]）。女性的钠摄入量与糖尿病风险之间也未显示出显著关联（第一四分位数：参照，第二四分位数：0.87 [0.69 - 1.09]，第三四分位数：1.02 [0.81 - 1.29]，第四四分位数：1.01 [0.76 - 1.33]）。此外，钾摄入量和钠钾比在男性和女性中均与糖尿病风险无显著关联。总之，在工作年龄的韩国成年人中，未观察到钠或钾的摄入量与糖尿病风险之间存在显著关联。
