PGAM5的生理和病理作用：最新进展与未来趋势
Physiological and pathological roles of PGAM5: An update and future trend.
作者信息
He Weibin, He Wenlong, Sun Zhongchan, He Pengcheng
机构信息
Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University, Guangzhou 510080, China.
Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Cardiovascular Institute, Guangzhou 510080, China.
出版信息
iScience. 2024 Dec 5;28(2):111539. doi: 10.1016/j.isci.2024.111539. eCollection 2025 Feb 21.
PGAM5, a phosphatase found in mitochondria, is crucial for mitochondrial quality control (MQC) through its regulation on mitochondrial dynamics, biogenesis, and mitophagy. Previous studies have shown its involvement in multiple regulated cell deaths (RCDs), including apoptosis, necroptosis, and pyroptosis. The objective of this review is to enhance our comprehension of the involvement of PGAM5 in MQC and RCDs. Additionally, we summarize some novel roles of PGAM5 in cellular senescence, lipid metabolism, and immune response modulation in recent studies. Finally, we discuss PGAM5's contribution to the pathological state of cardiovascular, hepatic, neurological, and neoplastic diseases, offering potential perspectives for future research.
PGAM5是一种存在于线粒体中的磷酸酶，通过对线粒体动力学、生物发生和线粒体自噬的调节，对线粒体质量控制（MQC）至关重要。先前的研究表明它参与多种程序性细胞死亡（RCD），包括细胞凋亡、坏死性凋亡和炎性小体介导的细胞焦亡。本综述的目的是加深我们对PGAM5参与MQC和RCD的理解。此外，我们总结了近期研究中PGAM5在细胞衰老、脂质代谢和免疫反应调节中的一些新作用。最后，我们讨论了PGAM5对心血管、肝脏、神经和肿瘤疾病病理状态的影响，为未来研究提供了潜在的方向。
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