Ahmed Rasha, Hamdy Omnia, Mohamed Abdulwehab Mona, Abdel-Halim Ibrahim, Soliman Amany Ahmed, Elattar Shaimaa
Urology Department, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt.
Engineering Applications of Lasers Department, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.
Lasers Med Sci. 2025 Feb 6;40(1):73. doi: 10.1007/s10103-025-04330-0.
To investigate the potential of nitric oxide (NO) and urinary nerve growth factor (NGF) as indicators of therapeutic outcomes in overactive bladder (OAB) patients undergoing low-level laser therapy (LLLT) via a prospective randomized controlled trial. Fifty OAB patients participated in the study and were subjected to LLLT using 650-nm laser irradiation. The study employed a prospective randomized controlled trial design. Nitric oxide and urine NGF levels were assessed before and after the LLLT intervention to evaluate their correlation with therapeutic outcomes. The study provided evidence supporting the effectiveness of LLLT as a treatment modality for OAB. Analysis of NO and urine NGF levels revealed significant changes following LLLT intervention suggesting their potential as biomarkers for assessing therapeutic response in OAB patients. These biomarkers hold promise for aiding clinicians in evaluating treatment response and personalizing therapy approaches for OAB patients. This study highlights the utility of LLLT in managing OAB and underscores the importance of exploring biomarkers such as nitric oxide and urinary nerve growth factor to enhance treatment efficacy assessment. The findings suggest that NO and urine NGF levels may serve as valuable indicators of therapeutic outcomes in OAB patients undergoing LLLT. Further research is warranted to elucidate the underlying mechanisms and optimize the clinical application of LLLT in OAB management.
通过一项前瞻性随机对照试验，研究一氧化氮（NO）和尿神经生长因子（NGF）作为膀胱过度活动症（OAB）患者接受低强度激光治疗（LLLT）疗效指标的潜力。50例OAB患者参与研究，接受650纳米激光照射的LLLT。该研究采用前瞻性随机对照试验设计。在LLLT干预前后评估一氧化氮和尿NGF水平，以评估它们与治疗效果的相关性。该研究提供了证据支持LLLT作为OAB治疗方式的有效性。对NO和尿NGF水平的分析显示，LLLT干预后有显著变化，表明它们有潜力作为评估OAB患者治疗反应的生物标志物。这些生物标志物有望帮助临床医生评估治疗反应并为OAB患者个性化治疗方法。本研究强调了LLLT在管理OAB中的效用，并强调了探索一氧化氮和尿神经生长因子等生物标志物以加强治疗效果评估的重要性。研究结果表明，NO和尿NGF水平可能作为接受LLLT的OAB患者治疗效果的有价值指标。有必要进一步研究以阐明潜在机制并优化LLLT在OAB管理中的临床应用。
