慢性血液透析患者铜和锌的变化

Changes in copper and zinc in chronic haemodialysis patients.

作者信息

Hosokawa S, Nishitani H, Imai T, Nishio T, Tomoyoshi T, Sawanishi K

出版信息

Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:247-50.

Abstract

We studied the behaviour of copper (Cu) and zinc (Zn) during haemodialysis (HD) in 65 chronic renal failure patients. Serum Cu, Zn and total protein were measured before and after dialysis. The dialyser membrane contained Cu and Zn. However, when the dialyser was washed with normal saline, Zn was removed, while Cu was liberated from the membrane during HD. We conclude that during HD serum Cu and Zn concentrations increased significantly (p less than 0.01), Cu from 98 to 120 micrograms/dl by haemoconcentration and liberation from the membrane, and Zn from 78 to 91 micrograms/dl by haemoconcentration.

摘要

我们研究了65例慢性肾衰竭患者血液透析（HD）过程中铜（Cu）和锌（Zn）的行为。在透析前后测定血清铜、锌和总蛋白。透析器膜含有铜和锌。然而，当用生理盐水冲洗透析器时，锌被去除，而铜在血液透析过程中从膜中释放出来。我们得出结论，在血液透析过程中血清铜和锌浓度显著升高（p小于0.01），铜通过血液浓缩和从膜中释放从98微克/分升升至120微克/分升，锌通过血液浓缩从78微克/分升升至91微克/分升。