Lv Bin, Zhang Tingyang, Wang Ning, Liu Lu, Li Mingyu, Li Meng, Sun Mingguang, Zang Xiao, Liu Xinfeng, Zhang Rongju, Cao Xiangyu, Du Zhihua, Wang Jun, Lyu Jinhao, Wang Xueyang, Duan Qi, Guo Fangfang, Lou Xin, Tian Chenglin
Department of Neurology, the First Medical Center, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, China.
Department of Radiology, the First Medical Center, Chinese PLA General Hospital, Beijing, China.
Sci Rep. 2025 Feb 7;15(1):4549. doi: 10.1038/s41598-025-87646-9.
Silent magnetic resonance angiography (S-MRA) is primarily utilized to assess the blood flow in aneurysms and parent vessels of treated intracranial aneurysms. This study aimed to compare the diagnostic value of S-MRA and three-dimensional time of flight (3D-TOF) MRA for unruptured intracranial aneurysms. We included patients diagnosed with unruptured intracranial aneurysms using digital subtraction angiography (DSA) who subsequently underwent S-MRA and 3D-TOF MRA. Two independent neuroimaging and neurointerventional doctors evaluated the DSA images and measured aneurysm dimensions. Using DSA results as the gold standard, we determined the sensitivity and specificity of S-MRA and 3D-TOF MRA, as well as their accuracy in measuring aneurysm size and identifying aneurysms with daughter sacs. We detected a total of 41 intracranial aneurysms (in 37 patients) on both S-MRA and 3D-TOF MRA, with both techniques achieving a sensitivity and specificity of 100%. For aneurysm height, the intraclass correlation coefficient (ICC) was 0.977 (P < 0.001) between S-MRA and DSA, and 0.908 (P < 0.001) between 3D-TOF MRA and DSA. For neck width, the ICC was 0.663 (P < 0.001) between S-MRA and DSA, and 0.563 (P < 0.001) between 3D-TOF MRA and DSA. In terms of daughter aneurysm detection, 3D-TOF MRA Sensitivity 40%; specificity 92%: positive predictive value 100%; S-MRA sensitivity 60%; specificity 89%; positive predictive value 42%. In conclusion, S-MRA and 3D-TOF MRA did not significantly differ in aneurysm detection ability. For the detection of aneurysm with dauthger sacs indicators, the sensitivity is also higher.
静态磁共振血管造影（S-MRA）主要用于评估颅内动脉瘤及已治疗颅内动脉瘤供血动脉的血流情况。本研究旨在比较S-MRA与三维时间飞跃法（3D-TOF）MRA对未破裂颅内动脉瘤的诊断价值。我们纳入了经数字减影血管造影（DSA）诊断为未破裂颅内动脉瘤且随后接受S-MRA和3D-TOF MRA检查的患者。两名独立的神经影像和神经介入医生评估DSA图像并测量动脉瘤尺寸。以DSA结果作为金标准，我们确定了S-MRA和3D-TOF MRA的敏感性和特异性，以及它们在测量动脉瘤大小和识别有子囊的动脉瘤方面的准确性。我们在S-MRA和3D-TOF MRA上共检测到41个颅内动脉瘤（37例患者），两种技术的敏感性和特异性均达到100%。对于动脉瘤高度，S-MRA与DSA之间的组内相关系数（ICC）为0.977（P＜0.001），3D-TOF MRA与DSA之间为0.908（P＜0.001）。对于瘤颈宽度，S-MRA与DSA之间的ICC为0.663（P＜0.001），3D-TOF MRA与DSA之间为0.563（P＜0.001）。在子动脉瘤检测方面，3D-TOF MRA敏感性为40%；特异性为92%；阳性预测值为100%；S-MRA敏感性为60%；特异性为89%；阳性预测值为42%。总之，S-MRA和3D-TOF MRA在动脉瘤检测能力上无显著差异。对于伴有子囊指标的动脉瘤检测，敏感性也较高。
