Gomi Takamasa, Okuda Itsuko, Seino Ami, Ohara Kaho, Harada Yasuko
Frontier Research Center, POLA Chemical Industries Inc., 560 Kashio-cho, Totsuka-ku, Yokohama, Kanagawa, 244-0812, Japan.
Department of Diagnostic Radiology, Mita Hospital, International University of Health and Welfare, Tokyo, Japan.
Sci Rep. 2025 Feb 6;15(1):4538. doi: 10.1038/s41598-025-89138-2.
Sunken upper eyelid is a morphological symptom that surrounds the eye with aging; however, its causes remain poorly understood. We investigated the correlations between the sunken upper eyelid and morphological parameters inside the eye area using magnetic resonance imaging (MRI), verified the relationship between age and degree of sunken upper eyelid photographically, and quantified muscle fibers histologically classified by myosin heavy chain (MYH) species and connective tissues in the superior palpebral part of the orbicularis oculi muscle from cadaveric specimens of various ages. The results showed the development of sunken upper eyelids, decreased thickness and number of MYH4-positive muscle fibers, and increased collagen and elastic fiber proportions in the orbicularis oculi muscle with age. On MRI, both the thickness of the orbicularis oculi muscle and the vertical position of the globe within the orbit were negatively correlated with the sunken upper eyelid. Changes in the orbicularis oculi muscle offer new insights into the mechanisms underlying age-related morphological changes in the periocular area.
上睑凹陷是一种随着年龄增长眼部周围出现的形态学症状；然而，其成因仍知之甚少。我们使用磁共振成像（MRI）研究了上睑凹陷与眼周区域内部形态学参数之间的相关性，通过照片验证了年龄与上睑凹陷程度之间的关系，并对来自不同年龄尸体标本的眼轮匝肌上睑部分中按肌球蛋白重链（MYH）种类组织学分类的肌纤维和结缔组织进行了量化。结果显示，随着年龄增长，上睑凹陷逐渐发展，眼轮匝肌中MYH4阳性肌纤维的厚度和数量减少，胶原蛋白和弹性纤维比例增加。在MRI上，眼轮匝肌厚度和眼球在眼眶内的垂直位置与上睑凹陷均呈负相关。眼轮匝肌的变化为眼周区域与年龄相关的形态学变化机制提供了新的见解。
