西咪替丁（H2受体阻滞剂）对犬肾自动调节功能的影响。

Cimetidine the H2-receptor blocker: effect on the renal autoregulation in dogs.

作者信息

Sobh M A

出版信息

Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:765-8.

Abstract

Two groups of female mongrel dogs were examined. The renal perfusion pressure (RPP) was decreased to 100 then to 85 and to 75 mmHg. The following parameters were measured: renal blood flow (RBF), glomerular filtration rate (GFR), ultraviolet (UV), UNaV and UPo4V. In the first group the autoregulation was found to be intact as the RBF and the GFR were kept constant in the face of a decreasing RPP. In the second group cimetidine infusion 10(-6) M/min caused 11 per cent reduction in the RBF. Reduction of the RPP to 75 mmHg caused a significant decrease in the RBF by 30 per cent and the UV by 50 per cent, the GFR was stable. This work demonstrates the depressive effect of cimetidine on the total RBF and its autoregulation.

摘要

对两组雌性杂种犬进行了检查。肾灌注压（RPP）先降至100 mmHg，然后降至85 mmHg，再降至75 mmHg。测量了以下参数：肾血流量（RBF）、肾小球滤过率（GFR）、尿钠排泄率（UNaV）和尿磷排泄率（UPo4V）。在第一组中，发现自动调节功能完好，因为在RPP降低时，RBF和GFR保持恒定。在第二组中，以10(-6) M/min的速度输注西咪替丁导致RBF降低了11%。将RPP降至75 mmHg导致RBF显著降低30%，尿钠排泄率降低50%，而GFR保持稳定。这项研究证明了西咪替丁对总肾血流量及其自动调节的抑制作用。