普萘洛尔对豚鼠和大鼠肺功能及支气管收缩反应性的影响。

Effect of propranolol on pulmonary function and bronchoconstrictor responsiveness in guinea pigs and rats.

作者信息

Chapman R W, Danko G, Siegel M I

出版信息

Pharmacol Res Commun. 1985 Feb;17(2):149-63. doi: 10.1016/0031-6989(85)90061-x.

Abstract

The beta-blocker propranolol was studied for its effects on basal pulmonary functions and on bronchoconstrictor responses to methacholine and histamine in mechanically ventilated guinea pigs and rats. Using doses that blocked the antibronchoconstrictor (bronchodilator) effects of the beta 2-agonist salbutamol, propranolol had no measurable effect on basal airway resistance and dynamic lung compliance in both guinea pigs and rats. However, bronchoconstrictor responses to methacholine and histamine were augmented by propranolol in guinea pigs. In contrast, propranolol did not change bronchoconstrictor responses to methacholine in rats. These results are discussed in terms of the functional role of pulmonary beta-receptors in guinea pigs and rats.

摘要

研究了β受体阻滞剂普萘洛尔对机械通气豚鼠和大鼠基础肺功能以及对乙酰甲胆碱和组胺支气管收缩反应的影响。使用能阻断β2激动剂沙丁胺醇抗支气管收缩（支气管扩张）作用的剂量时，普萘洛尔对豚鼠和大鼠的基础气道阻力和动态肺顺应性均无显著影响。然而，在豚鼠中，普萘洛尔增强了对乙酰甲胆碱和组胺的支气管收缩反应。相比之下，普萘洛尔对大鼠对乙酰甲胆碱的支气管收缩反应没有影响。根据豚鼠和大鼠肺β受体的功能作用对这些结果进行了讨论。