犬对前列腺素F2α、组胺和乙酰胆碱的支气管肺反应。

Bronchopulmonary responses to prostaglandin F2alpha, histamine and acetylcholine in the dog.

作者信息

Wasserman M A

出版信息

Eur J Pharmacol. 1975 Jun-Jul;32(02):146-55. doi: 10.1016/0014-2999(75)90277-0.

Abstract

This investigation compared quantitatively the effects of prostaglandin F2alpha, histamine and acetylcholine on pulmonary airway resistance and dynamic lung compliance in the spontaneously breathing, anesthetized dog. Airway responses were evaluated by computer analysis before and after pharmacological blockade by either atropine or propranolol. In a dose range of 1.0-10.0 mug/kg i.v., prostaglandin F2alpha was the most potent bronchoconstrictor studied. At the highest dose, prostaglandin F2alpha increased airway resistance 153.3% and decreased lung compliance 55.4% from basal levels. Similar doses of either histamine or acetylcholine produced much less effect. Atropine significantly reduced the bronchopulmonary responses evoked by histamine, acetylcholine and prostaglandin F2alpha. Propranolol did not inhibit any of the respiratory effects of those bronchoconstrictors analyzed. The bronchopulmonary effects of prostaglandin F2alpha and histamine appear to be augmented by cholinergic stimuli.

摘要

本研究定量比较了前列腺素F2α、组胺和乙酰胆碱对自主呼吸的麻醉犬肺气道阻力和动态肺顺应性的影响。在给予阿托品或普萘洛尔进行药理学阻断前后，通过计算机分析评估气道反应。静脉注射剂量范围为1.0 - 10.0μg/kg时，前列腺素F2α是所研究的最有效的支气管收缩剂。在最高剂量时，前列腺素F2α使气道阻力比基础水平增加153.3%，肺顺应性降低55.4%。相似剂量的组胺或乙酰胆碱产生的作用要小得多。阿托品显著降低了组胺、乙酰胆碱和前列腺素F2α引起的支气管肺反应。普萘洛尔并未抑制所分析的那些支气管收缩剂的任何呼吸效应。胆碱能刺激似乎增强了前列腺素F2α和组胺的支气管肺效应。