Karaja Saja, Almohamed Ahmad, Qatza Ayham, Aldolly Ahmed, Mansour Sanaa, Almasri Alae Aldin
University of Hama College of Human Medicine, Hama, Syria.
Ministry of Health, Hama National Hospital, Hama, Syria.
J Int Med Res. 2025 Feb;53(2):3000605251314804. doi: 10.1177/03000605251314804.
Cutaneous metastasis (CM) is a rare phenomenon, occurring in only 0.6% to 10.4% of oncology patients. Breast carcinoma represents nearly one-third of all CM cases, although it manifests in a minority of patients with breast cancer (BC). Notably, CMs are detected at the time of primary tumor diagnosis in 6.3% of patients with BC and serve as the initial clinical presentation in only 3.5% of patients. We present a case involving a 53-year-old woman with a 5-month history of asymptomatic infiltrating nodules in the axillae and trunk. Skin biopsy and immunohistochemical analysis confirmed metastatic breast carcinoma with positive estrogen receptor staining. This case underscores the importance of early detection and precise diagnostic techniques in managing metastatic adenocarcinoma with cutaneous manifestations. Despite the promising outcome of the initial treatment, the disease progression in this case highlights the aggressive nature of CMs and the ongoing need for research and advanced therapeutic strategies.
皮肤转移（CM）是一种罕见现象，仅发生在0.6%至10.4%的肿瘤患者中。乳腺癌占所有CM病例的近三分之一，尽管它在少数乳腺癌（BC）患者中表现出来。值得注意的是，6.3%的BC患者在原发性肿瘤诊断时检测到CM，而仅3.5%的患者以CM作为初始临床表现。我们报告一例53岁女性病例，其腋窝和躯干有无症状浸润性结节5个月病史。皮肤活检和免疫组化分析证实为雌激素受体染色阳性的转移性乳腺癌。该病例强调了早期检测和精确诊断技术在管理有皮肤表现的转移性腺癌中的重要性。尽管初始治疗结果良好，但该病例中的疾病进展突出了CM的侵袭性以及对研究和先进治疗策略的持续需求。
