Barcsay-Veres Amarilla, Csorba Anita, Kovacs Illes, Tothfalusi Laszlo, Maneschg Otto Alexander
Department of Ophthalmology, Semmelweis University, Maria Str. 39, Budapest, H-1085, Hungary.
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.
Sci Rep. 2025 Feb 8;15(1):4671. doi: 10.1038/s41598-025-85256-z.
Ocular surface inflammation due to allergy and blepharitis can lead to corneal complications and visual impairment. The aim of this study is to evaluate the efficacy of a cyclosporin 0.1% topical treatment achieving steroid-sparing. Eighty pediatric patients with moderate and severe vernal and blepharitis-related keratoconjunctivitis were included. Symptoms (photosensitivity, itching, discharge, tearing), signs (corneal fluorescein staining, papillary hypertrophy) and patients' subjective assessment were evaluated during a 6-month follow-up. At the follow-up, all patients treated with topical cyclosporin showed a significant improvement in all subjective symptoms and objective signs (p < 0.001). The total number of courses of rescue steroids courses decreased from 3.71 ± 1.72 to 0.25 ± 0.49 at month 3 and to 0.13 ± 0.38 dropping bottle at month 6 (p < 0.001 at both time points). The 96.1% of the allergic cohort and 96.4% of the blepharitis cohort experienced a satisfactory good or rapid and good effect during the 6-month follow-up. The probability of needing rescue corticosteroids increased with an odds ratio of 1.98, (95% CI: 1.19-3.28, p = 0.008) for each unit increase in Oxford score when analysing the whole cohort. Topical cyclosporin seems to be very effective reducing the number of recurrences of corneal involvement and the need for steroid treatment.
过敏和睑缘炎引起的眼表炎症可导致角膜并发症和视力损害。本研究的目的是评估0.1%环孢素局部治疗实现类固醇节省的疗效。纳入了80例患有中度和重度春季角结膜炎及睑缘炎相关性角结膜炎的儿科患者。在6个月的随访期间，对症状（光敏、瘙痒、分泌物、流泪）、体征（角膜荧光素染色、乳头肥大）和患者的主观评估进行了评价。随访时，所有接受局部环孢素治疗的患者在所有主观症状和客观体征方面均有显著改善（p < 0.001）。急救类固醇疗程总数在第3个月时从3.71±1.72降至0.25±0.49，在第6个月时降至0.13±0.38（两个时间点p均< 0.001）。在6个月的随访期间，96.1%的过敏组和96.4%的睑缘炎组经历了满意的良好或快速且良好的效果。在分析整个队列时，牛津评分每增加一个单位，需要急救皮质类固醇的概率增加，优势比为1.98（95%可信区间：1.19 - 3.28，p = 0.008）。局部环孢素似乎在减少角膜受累复发次数和类固醇治疗需求方面非常有效。
