Golovchak Roman, Mahlovanyi Bohdan, Shpotyuk Yaroslav, Kus-Liskiewicz Malgorzata, Kozianska Julia, Zadrag-Tecza Renata, Zagula Grzegorz, Trzyna-Sowa Malgorzata, Kovalskiy Andriy, Gala-Bladzinska Agnieszka, Cebulski Jozef
Department of Physics, Engineering and Astronomy, Austin Peay State University, Clarksville, TN, 37044, USA.
Institute of Physics, Rzeszow University, 35-959, Rzeszów, Poland.
Sci Rep. 2025 Feb 8;15(1):4677. doi: 10.1038/s41598-025-88781-z.
The emergence of antibiotic-resistant strains caused by the extensive use of antibiotics in the world requires a preventive approach to stop the infection spread, especially in a hospital setting. So, there is a growing demand for materials that can inhibit bacteria growth or have bactericidal effects. In this paper, an inexpensive and durable Cu-containing strontium-modified phosphate glass with a considerable antimicrobial effect is proposed. The basic physical properties of the material are studied, and its antimicrobial effect is evaluated on Staphylococcus aureus bacteria, known to be the most common problem in hospital environments because of healthcare-associated infections. The glass powders demonstrate strong antibacterial efficacy with a concentration of only a few mg/mL, sufficient to eradicate the entire bacterial colonies within 24 h. Bulk surfaces of these glasses inhibit bacterial growth and release low, non-toxic levels of their constituent elements into simulated body fluid. On the basis of the obtained results, it is shown that the proposed glass can be used as a structural material for various medical equipment and/or components of antimicrobial coating/paint not only in medicine but also for high touch point articles in public places like schools, gyms, public offices and similar.
全球抗生素的广泛使用导致了抗生素耐药菌株的出现,这就需要采取预防措施来阻止感染传播,尤其是在医院环境中。因此,人们对能够抑制细菌生长或具有杀菌作用的材料的需求日益增长。本文提出了一种价格低廉且耐用的含铜锶改性磷酸盐玻璃,它具有相当显著的抗菌效果。研究了该材料的基本物理性能,并针对金黄色葡萄球菌评估了其抗菌效果,金黄色葡萄球菌因医疗相关感染而成为医院环境中最常见的问题。玻璃粉末在浓度仅为几毫克/毫升时就表现出很强的抗菌功效,足以在24小时内根除所有细菌菌落。这些玻璃的块状表面能抑制细菌生长,并将其组成元素以低毒水平释放到模拟体液中。根据所得结果表明,所提出的玻璃不仅可作为各种医疗设备的结构材料,和/或用于抗菌涂层/涂料的组件,不仅在医学领域,还可用于学校、体育馆、公共办公室等公共场所的高接触物品。