Wang Ziyi, Wu Chao, Yin Dong, Dou Kefei
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cardiometabolic Medicine Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cardiovasc Diabetol. 2025 Feb 7;24(1):60. doi: 10.1186/s12933-025-02614-x.
Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular death characterized by lipid peroxidation, is involved in the pathogenesis of diabetic cardiovascular diseases. The susceptibility to ferroptosis in diabetic hearts is possibly related to myocardial iron accumulation, abnormal lipid metabolism and excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests ferroptosis can be the therapeutic target for diabetic cardiovascular diseases. This review summarizes ferroptosis-related mechanisms in the pathogenesis of diabetic cardiovascular diseases and novel therapeutic choices targeting ferroptosis-related pathways. Further study on ferroptosis-mediated cardiac injury can enhance our understanding of the pathophysiology of diabetic cardiovascular diseases and provide more potential therapeutic choices.
心血管疾病是糖尿病患者死亡和合并症的主要原因。铁死亡是一种铁依赖性非凋亡调节性细胞死亡，其特征为脂质过氧化，参与糖尿病心血管疾病的发病机制。糖尿病心脏对铁死亡的易感性可能与心肌铁蓄积、脂质代谢异常以及高血糖条件下的氧化应激增加有关。越来越多的证据表明，铁死亡可能是糖尿病心血管疾病的治疗靶点。本文综述了糖尿病心血管疾病发病机制中与铁死亡相关的机制以及针对铁死亡相关途径的新型治疗选择。对铁死亡介导的心脏损伤进行进一步研究，有助于加深我们对糖尿病心血管疾病病理生理学的理解，并提供更多潜在的治疗选择。
