Herzog Joshua P, Rosenthal Amy, Ragupathi Dakshith, Brown Erin L, Bucklen Brandon S
Spine Surgery, OrthoVirginia, Richmond, USA.
Clinical Affairs, Globus Medical Inc., Audubon, USA.
Cureus. 2025 Jan 8;17(1):e77138. doi: 10.7759/cureus.77138. eCollection 2025 Jan.
Degenerative adult spinal deformity (ASD) is a prevalent disease in the elderly population. Treating it typically requires an extensive surgical intervention. This study aimed to assess the use of expandable spacers for multi-level anterior-to-psoas lumbar interbody fusion (ATP-LIF) along with posterior direct decompression and osteotomy to treat patients with degenerative ASD.
This was a single-center retrospective study of ASD patients (anyone undergoing fusion procedure for four or more spinal levels) undergoing two-stage surgery with expandable interbody spacers with a minimum follow-up period of around 12 months between November 2019 and June 2021. A total of 20 patients were enrolled in this study (15 patients = four-level fusion, five patients = five-level fusion). Exclusion criteria included <18 years of age, pregnancy, tumor, and trauma patients. Demographic, surgical, radiographic, complications, and patient-reported outcomes (PROs) were collected.
Of the 20 patients included (mean age = 68.1 ± 9.0 years, mean body mass index = 30.5 ± 7.4 kg/m, 12 males and eight females), surgical data showed a mean total operation time of 315 ± 180.6 mins and mean total blood loss of 638.8 ± 37.6 mL. At 12 months, 18/20 patients returned for follow-up. There was a significant reduction in the mean visual analog scale (VAS) back pain scores (Δ = 2.1, p < 0.05), an increase in the 12-item short-form health survey (SF-12) (Δ = 5.6, p < 0.05), and improvement in pelvic incidence-lumbar lordosis (PI-LL) (Δ = 15.8°, p < 0.05) at the final follow-up, as compared with the preoperative baseline. Moreover, at 12 months follow-up, radiographic data showed 100% fusion rate (18/18), lumbar lordosis (Δ = 13.9°), and disc height improvement (Δ = 4.1 mm), as well as a reduction in the coronal cobb angle (Δ = 6.9°) as compared to the preoperative baseline.
Two-stage ATP-LIF with expandable spacers along with posterior direct decompression and Ponte osteotomy is a viable minimally invasive treatment for patients with ASD. This was evidenced by similar surgical outcomes to pedicle subtraction osteotomy, improvements in PROs, restoration of PI-LL, high fusion rates, and a significant increase in disc height.
退行性成人脊柱畸形(ASD)是老年人群中的一种常见疾病。治疗该病通常需要进行广泛的手术干预。本研究旨在评估可扩张椎间融合器在多节段腰大肌前方腰椎椎间融合术(ATP-LIF)中的应用,并联合后路直接减压和截骨术来治疗退行性ASD患者。
这是一项单中心回顾性研究,研究对象为2019年11月至2021年6月期间接受两阶段手术且使用可扩张椎间融合器的ASD患者(任何接受四个或更多脊柱节段融合手术的患者),最短随访期约为12个月。本研究共纳入20例患者(15例患者为四级融合,5例患者为五级融合)。排除标准包括年龄<18岁、妊娠、肿瘤和创伤患者。收集了人口统计学、手术、影像学、并发症及患者报告结局(PROs)等数据。
纳入的20例患者(平均年龄=68.1±9.0岁,平均体重指数=30.5±7.4kg/m²,1男和8女),手术数据显示平均总手术时间为315±180.6分钟,平均总失血量为638.8±37.6毫升。12个月时,20例患者中有18例返回接受随访。与术前基线相比,末次随访时平均视觉模拟量表(VAS)背痛评分显著降低(Δ=2.1,p<0.05),12项简短健康调查问卷(SF-12)得分增加(Δ=5.6,p<0.05),骨盆入射角-腰椎前凸(PI-LL)改善(Δ=15.8°,p<0.05)。此外,在12个月随访时,影像学数据显示融合率为100%(18/18),腰椎前凸(Δ=13.9°),椎间盘高度改善(Δ=4.1毫米),与术前基线相比,冠状面Cobb角减小(Δ=6.9°)。
两阶段ATP-LIF联合可扩张椎间融合器以及后路直接减压和Ponte截骨术是治疗ASD患者的一种可行的微创治疗方法。椎弓根截骨术的手术效果相似、PROs改善、PI-LL恢复、融合率高以及椎间盘高度显著增加均证明了这一点。