先天性巨结肠症中的人类白细胞抗原

HLA antigens in Hirschsprung's disease.

作者信息

Kogan J, Wentzel J, Roberts D F, Scott J E

出版信息

Tissue Antigens. 1985 Feb;25(2):79-82. doi: 10.1111/j.1399-0039.1985.tb00418.x.

DOI:10.1111/j.1399-0039.1985.tb00418.x

Abstract

In 55 children with Hirschsprung's disease, 64 of their normal siblings and 120 other members of their families, HLA-A, B and C types were examined. The statistical significance of the raised incidence of A1, B14, B37 and Bw35 in the patients disappeared after correction for multiple testing. The levels of homozygosity were very similar in patients and normal controls. The results indicate no direct association of the disease with HLA type.

摘要

对55例患有先天性巨结肠症的儿童、64名其正常的兄弟姐妹以及120名其他家庭成员进行了HLA - A、B和C型检测。在对多重检验进行校正后，患者中A1、B14、B37和Bw35发生率升高的统计学显著性消失。患者和正常对照组的纯合性水平非常相似。结果表明该疾病与HLA类型无直接关联。