Muñoz-Caro Tamara, Saraiva Elvira M, Mariante Rafael M
Escuela de Medicina Veterinaria, Facultad de Medicina Veterinaria y Recursos Naturales, Universidad Santo Tomás, Talca, Chile.
Laboratório de Imunidade Inata, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Front Immunol. 2025 Jan 24;16:1498453. doi: 10.3389/fimmu.2025.1498453. eCollection 2025.
Parasitic diseases pose a significant global public health challenge, affecting billions of people and causing substantial economic losses in livestock and poultry. In the fight against these infections, neutrophils play a crucial role, employing various strategies, including the release of neutrophil extracellular traps (NETs). Recent studies have made significant progress in understanding NETs triggered by protozoa and helminths. However, a comprehensive bibliometric analysis that compiles these findings and identifies research hotspots and trends in this field is still lacking.
We utilized the Web of Science Core Collection and Scopus databases to retrieve original articles on NETs induced by protozoa and helminths. After screening, the data was transferred to the visualization tools VOSviewer, Biblioshiny, and CiteSpace for analysis.
Our study included 159 original articles published in 69 journals, involving 909 authors from 270 institutions across 41 countries. Germany and Brazil have made the most significant contributions to the research on NETs and parasites, accounting for 45 and 32 publications, and 1,495 and 1,342 citations, respectively. Carlos Hermosilla and Anja Taubert (Justus Liebig University Giessen, Germany), and Elvira Saraiva (Federal University of Rio de Janeiro, Brazil), are leaders in the field, both in terms of publication output and citations. has consistently and significantly impacted the field, and an article in the providing the first direct evidence of NETs release in response to a parasite is by far the most cited. Current research focuses on malaria, , , nematodes, and the mechanisms of NETs production and their effects on parasites and host cells. Emerging trends include therapeutic targeting of NETs and comparative studies across different host and parasite species.
This study offers a comprehensive overview and visual analysis of NETs and parasites, highlighting key areas for future research.
寄生虫病是一项重大的全球公共卫生挑战，影响着数十亿人，并给家畜和家禽造成巨大经济损失。在对抗这些感染的过程中，中性粒细胞发挥着关键作用，采用多种策略，包括释放中性粒细胞胞外陷阱（NETs）。最近的研究在理解由原生动物和蠕虫引发的NETs方面取得了重大进展。然而，仍缺乏一项全面的文献计量分析来汇总这些发现，并确定该领域的研究热点和趋势。
我们利用科学网核心合集和Scopus数据库检索关于原生动物和蠕虫诱导的NETs的原始文章。筛选后，将数据转移到可视化工具VOSviewer、Biblioshiny和CiteSpace进行分析。
我们的研究纳入了发表在69种期刊上的159篇原始文章，涉及来自41个国家270个机构的909位作者。德国和巴西对NETs与寄生虫研究的贡献最大，分别有45篇和32篇出版物，以及1495次和1342次引用。卡洛斯·埃尔莫西利亚和安雅·陶伯特（德国吉森尤斯·李比希大学）以及埃尔维拉·萨拉伊瓦（巴西里约热内卢联邦大学）在发表量和引用量方面都是该领域的领军人物。 一直对该领域有显著影响，一篇发表在 上的文章提供了NETs释放以响应寄生虫的首个直接证据，是被引用最多的。当前研究集中在疟疾、 、 、线虫以及NETs产生的机制及其对寄生虫和宿主细胞的影响。新出现的趋势包括对NETs的治疗靶向以及跨不同宿主和寄生虫物种的比较研究。
本研究对NETs与寄生虫进行了全面概述和可视化分析，突出了未来研究的关键领域。
