Hicks H E, Spalding P M, Banes A J
Toxicol Lett. 1985 Apr;25(1):41-6. doi: 10.1016/0378-4274(85)90098-0.
The growth of developing A/J mouse embryos was studied after maternal administration of phenytoin (Dilantin), an anticonvulsant drug. Wet weight, dry weight, protein and DNA contents of the embryos were quantitated 24 h after drug administration. Collagen content was investigated because of its importance in cellular differentiation. The wet and dry weight of embryos from phenytoin-treated mothers were 52.3 and 57.5%, respectively, of that of embryos of control mothers. DNA and protein contents were also decreased in embryos from phenytoin-treated mothers. Collagen represented only 0.07% of the protein present in day 11 control embryos, but was increased 4.9-fold in embryos from phenytoin-treated mothers in comparison to controls. These results suggest that phenytoin reduces overall embryonic growth but stimulates collagen synthesis.
在给怀孕的A/J小鼠母体施用抗惊厥药物苯妥英钠（地伦丁）后，对发育中的A/J小鼠胚胎的生长情况进行了研究。在给药24小时后，对胚胎的湿重、干重、蛋白质和DNA含量进行了定量分析。由于胶原蛋白在细胞分化中的重要性，对其含量也进行了研究。经苯妥英钠处理的母体所产胚胎的湿重和干重分别为对照母体所产胚胎的52.3%和57.5%。经苯妥英钠处理的母体所产胚胎的DNA和蛋白质含量也有所下降。胶原蛋白在第11天对照胚胎的蛋白质中仅占0.07%，但与对照组相比，经苯妥英钠处理的母体所产胚胎中的胶原蛋白增加了4.9倍。这些结果表明，苯妥英钠会降低胚胎的整体生长，但会刺激胶原蛋白的合成。
