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使用美国登记数据库研究新冠病毒疾病(COVID-19)与儿童院外心脏骤停的关系

COVID-19 and pediatric out-of-hospital cardiac arrest using U.S. registry database.

作者信息

Schmitt Christopher, Beasley Gary, Guerrier Karine, Kramer Jennifer, Naim Maryam Y, Griffis Heather, McNally Bryan, Chan Paul S, Al-Araji Rabab, Rossano Joseph

机构信息

University of Tennessee Health Science Center, Memphis, TN, United States.

University of Iowa, Iowa City, IA, United States.

出版信息

Resusc Plus. 2025 Jan 11;22:100869. doi: 10.1016/j.resplu.2025.100869. eCollection 2025 Mar.

Abstract

BACKGROUND

Out-of-hospital cardiac arrests (OHCA) increased in the adult population during the COVID pandemic..

OBJECTIVES

We aimed to determine if OHCAs increased in the pediatric population during the COVID pandemic and whether the pandemic exacerbated pre-existing racial and socio-economic disparities..

METHODS

Utilizing data from 2015 to 2020 from the Cardiac Arrest Registry to Enhance Survival (CARES) database, 13,513 pediatric OHCAs were analyzed. Age categories included infants (0-<1 year), children (1-12 years) and adolescents (13-18 years). This included information on patient demographics, use of CPR (cardiopulmonary resuscitation) or AED (automatic external defibrillator), outcomes, COVID prevalence, and socioeconomic variables.

RESULTS

In the pediatric population, there was no increase in OHCAs during the COVID pandemic, however in the adolescent population there was an increase in OHCA incidence from 0.29 to 0.40 arrests per 1 million total residents ( < 0.0001), and a decrease in the infant population from 0.861 to 0.803 events per 1 million total residents ( = 0.02). The pandemic worsened the burden of OHCAs in communities with lower socioeconomic status and in which COVID was more prevalent. Disparities of CPR or AED use and survival outcomes were seen based on race, sex, and socioeconomic factors, however none of these disparities were further augmented by the COVID pandemic.

CONCLUSIONS

Adolescent populations showed higher rates of OHCAs during the COVID pandemic, especially in areas with higher COVID incidence. Infants, however, had slightly decreased rates, which may be related to changes in other respiratory infections, and parental behavioral changes during the pandemic.

摘要

背景

在新冠疫情期间,成年人群院外心脏骤停(OHCA)的发生率有所上升。

目的

我们旨在确定新冠疫情期间儿科人群的院外心脏骤停发生率是否上升,以及疫情是否加剧了原有的种族和社会经济差异。

方法

利用2015年至2020年心脏骤停登记以提高生存率(CARES)数据库的数据,对13513例儿科院外心脏骤停病例进行了分析。年龄类别包括婴儿(0至<1岁)、儿童(1至12岁)和青少年(13至18岁)。这包括患者人口统计学信息、心肺复苏(CPR)或自动体外除颤器(AED)的使用情况、结局、新冠感染率以及社会经济变量。

结果

在儿科人群中,新冠疫情期间院外心脏骤停发生率没有上升,然而在青少年人群中,院外心脏骤停发生率从每100万居民0.29例上升至0.40例(P<0.0001),而婴儿人群发生率从每100万居民0.861例降至0.803例(P=0.02)。疫情加重了社会经济地位较低且新冠感染率较高社区的院外心脏骤停负担。基于种族、性别和社会经济因素,在心肺复苏或自动体外除颤器使用以及生存结局方面存在差异,然而这些差异均未因新冠疫情而进一步扩大。

结论

在新冠疫情期间,青少年人群的院外心脏骤停发生率较高,尤其是在新冠感染率较高的地区。然而,婴儿的发生率略有下降,这可能与其他呼吸道感染的变化以及疫情期间家长行为的改变有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f557/11803234/eebd434cfb74/gr1.jpg

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