Kumar Harsh, Sandhu Rameet, Upadhyay Ritesh, Aggarwal Aanchal, Rela Rathi, Karthik Sahana
Department of Dentistry, Patna Medical College, Patna, Bihar, India.
Department of Oral and Maxillofacial Surgery, Luxmi Bai Institute of Dental Sciences and Hospital, Sirhind Road, Patiala, Punjab, India.
J Pharm Bioallied Sci. 2024 Dec;16(Suppl 4):S4091-S4093. doi: 10.4103/jpbs.jpbs_1436_24. Epub 2024 Dec 27.
Human papillomavirus (HPV) has been linked as a potential risk factor for increasing incidence of oropharyngeal carcinoma.
The present study aimed to evaluate the role of clinicopathologic factors in outcome prediction in subjects having oropharyngeal carcinoma associated with HPV and managed with surgery.
The present retrospective study assessed data from 54 subjects that were diagnosed with stage III or IV HPV-associated oropharyngeal carcinoma were managed with surgery with or without adjuvant therapy.
The mean follow-up duration in the study subjects was 2.7 years. The recurrence-free survival and overall survival rates [age, number of lymph nodes involved, stage of tumor, and Charleston comorbidity index] in the study subjects were 83% and 71% and 62% and 79%, respectively. The recurrence rate in the study was found to be 21%.
The conclusion drawn from the present study is that some associated potential risk factors can have lesser relevance in HPV-associated oropharyngeal carcinoma.
人乳头瘤病毒（HPV）已被认为是口咽癌发病率上升的潜在风险因素。
本研究旨在评估临床病理因素在与HPV相关且接受手术治疗的口咽癌患者预后预测中的作用。
本回顾性研究评估了54例被诊断为III期或IV期HPV相关口咽癌患者的数据，这些患者接受了手术治疗，部分患者还接受了辅助治疗。
研究对象的平均随访时间为2.7年。研究对象的无复发生存率和总生存率（年龄、受累淋巴结数量、肿瘤分期和查尔斯顿合并症指数）分别为83%和71%，以及62%和79%。研究发现复发率为21%。
本研究得出的结论是，一些相关的潜在风险因素在HPV相关口咽癌中可能相关性较小。
