酒精相关性涎腺肿大患者肝脏和胰腺功能的评估——一项病例对照研究
Evaluation of the Liver and Pancreatic Functions in Patients with Alcohol-Related Sialadenosis - A Case Control Study.
作者信息
Elavarasi E, Gunasekaran Vinothini, Thirumal Mohan, Subramaniyan R Balaji, Austin Ravi David, Thirumalai S
机构信息
Department of Dentistry, Aarupadai Veedu Medical College and Hospital, Vinayaka Missions Research Foundation, (Deemed to be University), Kirumampakkam, Puducherry, India.
Department of Dentistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India.
出版信息
J Pharm Bioallied Sci. 2024 Dec;16(Suppl 4):S3580-S3582. doi: 10.4103/jpbs.jpbs_1053_24. Epub 2024 Oct 30.
BACKGROUND
Sialadenosis or sialosis is the asymptomatic symmetric parotid enlargement without inflammation or neoplasia, seen in persons 30-69 years old, often related to chronic alcohol use, endocrine disorders, and obesity.
MATERIALS AND METHODS
This was a case-control study done at Rajah Muthiah Dental College and Hospital from September 2013 to July 2014, comprising 15 patients with alcoholic sialadenosis (Group A) and comparing them with 15 alcoholic patients without sialadenosis (Group B). Parameters monitored for liver and pancreatic functions were their serum levels of AST, ALT, GGT, ALP, amylase, and lipase.
RESULTS
Group A had higher mean levels of GGT, AST, and ALT; a slightly increased AST/ALT ratio; and high serum amylase and lipase compared to Group B. Both groups consumed ethanol in excess.
CONCLUSION
Biochemical differences suggest chronic alcohol effects on sialadenosis. Stable hepatic and pancreatic functions indicate that further research into sialadenosis may provide a potential diagnostic marker for liver and pancreatic disorders.
背景
涎腺肿大症或涎osis是指在30 - 69岁人群中出现的无症状性双侧腮腺肿大，无炎症或肿瘤形成，常与长期饮酒、内分泌紊乱及肥胖有关。
材料与方法
这是一项于2013年9月至2014年7月在拉贾·穆西亚牙科学院及医院开展的病例对照研究，纳入15例酒精性涎腺肿大症患者（A组），并与15例无涎腺肿大症的酒精性患者（B组）进行比较。监测肝脏和胰腺功能的参数包括血清AST、ALT、GGT、ALP、淀粉酶和脂肪酶水平。
结果
与B组相比，A组的GGT、AST和ALT平均水平更高；AST/ALT比值略有升高；血清淀粉酶和脂肪酶水平较高。两组均过量饮酒。
结论
生化差异提示长期饮酒对涎腺肿大症有影响。肝脏和胰腺功能稳定表明，对涎腺肿大症的进一步研究可能为肝脏和胰腺疾病提供潜在的诊断标志物。
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