Gagliardi Melynda, Asghari Bita
Eyes on Weston, 10-8633 Weston Road, Vaughan, ON, L4L9R6, Canada.
BostonSight, 464 Hillside Ave, Needham, MA, 02494, USA.
Am J Ophthalmol Case Rep. 2025 Jan 19;37:102261. doi: 10.1016/j.ajoc.2025.102261. eCollection 2025 Mar.
This case series describes the therapeutic application of customized scleral lenses via prosthetic replacement of the ocular surface ecosystem (PROSE) in patients with Keratitis-Ichthyosis-Deafness (KID) syndrome. It proposes PROSE or scleral lens wear as a therapeutic option for KID syndrome.
Two patients with KID syndrome were successfully fitted with PROSE devices, also referred to as prosthetic devices, and continued with wear. The duration of lens wear ranged from one to seven years. One patient was pediatric with severe disease, and the other an adult with milder disease. The pediatric patient had challenges with application and removal and ultimately discontinued device wear; however, demonstrated improvement in corneal surface health through duration of wear for the right eye. The second patient continued with device wear for seven years, with resolution of recurrent corneal erosions, improved comfort and stabilization of corneal surface health. Both patients had benefit with PROSE device wear.
Management of ocular surface disease in KID syndrome can be challenging with limited therapeutic options including poor surgical outcomes. This case series supports the therapeutic application of scleral lenses in patients with KID syndrome.
本病例系列描述了通过眼表生态系统修复术（PROSE）定制巩膜镜在角膜炎-鱼鳞病-耳聋（KID）综合征患者中的治疗应用。它提出将PROSE或巩膜镜佩戴作为KID综合征的一种治疗选择。
两名KID综合征患者成功佩戴了PROSE装置（也称为修复装置）并持续佩戴。镜片佩戴时间为1至7年。一名患者为患有严重疾病的儿童，另一名为患有较轻疾病的成年人。儿童患者在佩戴和取下装置方面存在困难，最终停止了装置佩戴；然而，通过右眼佩戴期间的观察，其角膜表面健康状况有所改善。第二名患者持续佩戴装置7年，复发性角膜糜烂得到解决，舒适度提高，角膜表面健康状况稳定。两名患者佩戴PROSE装置均有获益。
KID综合征眼表疾病的管理具有挑战性，治疗选择有限，包括手术效果不佳。本病例系列支持巩膜镜在KID综合征患者中的治疗应用。
