Intan Putri Reno, Alegantina Sukmayati, Isnawati Ani, Yunarto Nanang, Ekawasti Fitrine, Rinendyaputri Ratih, Sunarno Sunarno, Sani Yulvian, Mariya Sela Septima, Handharyani Ekowati
Animal Biomedical Study Program, IPB Postgraduate School, School of Veterinary Medicine and Biomedicine, IPB University, Bogor, Indonesia.
Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Bogor, Indonesia.
Open Vet J. 2024 Dec;14(12):3630-3639. doi: 10.5455/OVJ.2024.v14.i12.44. Epub 2024 Dec 31.
Breastfeeding is vital for infant health, providing essential nutrients and protection against infections. Despite the benefits, many postpartum women face challenges in breastfeeding due to hypogalactia caused by stress, anxiety, or maternal illness. While medications, such as metoclopramide and domperidone, are sometimes prescribed to increase milk supply, they are limited due to safety concerns. As a result, there is a growing interest in alternative nonpharmacological interventions, including herbal galactagogues. Plants, such as , , and , have shown potential in enhancing milk production due to their unique lactogenic properties.
This study aimed to investigate the influence of a combination of , , and extracts on milk production while assessing whether these extracts possess galactagogue properties.
Twenty-four Sprague-Dawley rats were randomly divided into four groups at parturition. Each group, comprising six dams, was assigned a specific dose of 37.5, 75, and 150 mg/kg of the blended extract orally for 20 days postpartum, with one group serving as the control. Mammary glands were harvested and assayed for prolactin expression by immunohistochemistry.
The results showed that while the rate of milk production did not increase linearly with the duration of lactation, rats treated with the blended extract at a dose of 75 mg/kg exhibited higher milk production than the control group. Immunohistochemical analysis revealed increased prolactin expression in the mammary glands of rats treated with blend extract at 37.5 mg/kg ( < 0.05), suggesting its potential as a galactagogue.
The blended extract of , , and may stimulate milk production by modulating prolactin expression and mammary gland morphology.
母乳喂养对婴儿健康至关重要，可提供必需营养素并预防感染。尽管有诸多益处，但许多产后女性因压力、焦虑或母体疾病导致乳汁分泌不足，在母乳喂养方面面临挑战。虽然有时会开一些药物，如甲氧氯普胺和多潘立酮来增加乳汁分泌，但由于安全问题，其应用受到限制。因此，人们对包括草药催乳剂在内的替代性非药物干预措施的兴趣日益浓厚。诸如[此处原文缺失具体植物名称]等植物，因其独特的催乳特性，在提高乳汁分泌方面显示出潜力。
本研究旨在调查[此处原文缺失具体植物名称]提取物组合对乳汁分泌的影响，同时评估这些提取物是否具有催乳特性。
24只Sprague-Dawley大鼠在分娩时随机分为四组。每组由六只母鼠组成，产后20天口服给予特定剂量的37.5、75和150mg/kg混合提取物，一组作为对照组。采集乳腺并通过免疫组织化学法检测催乳素表达。
结果表明，虽然乳汁分泌率并未随哺乳时间呈线性增加，但给予75mg/kg混合提取物处理的大鼠乳汁分泌量高于对照组。免疫组织化学分析显示，给予37.5mg/kg混合提取物处理的大鼠乳腺中催乳素表达增加（P<0.05），表明其具有催乳潜力。
[此处原文缺失具体植物名称]的混合提取物可能通过调节催乳素表达和乳腺形态来刺激乳汁分泌。
