Kim Bo-Guen, Lee Hyun, Eun Yeonghee, Han Kyungdo, Jung Jin-Hyung, Choi Hayoung, Kim Hyungjin, Shin Dong Wook
Division of Pulmonary Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
Sci Rep. 2025 Feb 10;15(1):4885. doi: 10.1038/s41598-025-88323-7.
Interstitial lung disease (ILD) leads to worse outcomes in subjects with rheumatoid arthritis (RA). Few large-scale longitudinal studies have provided comprehensive data on the incidence and risk of ILD in RA compared with non-RA populations. We compare the risk of incident ILD in subjects with RA and matched controls, while also evaluating the impact of RA serologic status. Using the Korean National Health Insurance Service Data between 2010 and 2017, we identified 52,325 individuals with RA and 261,625 without RA. During a median follow-up period of 4.4 years, 3.7% of the RA cohort and 0.5% of the matched cohort developed ILD, with incidence rates of 8.30 and 1.01 per 1,000 person-years. Compared to controls, the risk of incident ILD was significantly higher in the RA cohort (adjusted hazard ratio [aHR] 7.84 [7.29-8.44]), and seropositive and seronegative RA exhibited aHRs of 9.00 (8.34-9.72) and 4.81 (4.25-5.44). Although the risk of ILD was higher in seropositive RA than seronegative RA, the risk of developing ILD was also higher in subjects with seronegative RA than in matched controls, suggesting that close monitoring for ILD should be performed in this population.
间质性肺疾病（ILD）会导致类风湿关节炎（RA）患者出现更差的预后。与非RA人群相比，很少有大规模纵向研究提供关于RA中ILD发病率和风险的全面数据。我们比较了RA患者和匹配对照组发生ILD的风险，同时还评估了RA血清学状态的影响。利用2010年至2017年韩国国民健康保险服务数据，我们确定了52325例RA患者和261625例非RA患者。在中位随访期4.4年期间，RA队列中的3.7%和匹配队列中的0.5%发生了ILD，发病率分别为每1000人年8.30例和1.01例。与对照组相比，RA队列中发生ILD的风险显著更高（调整后风险比[aHR]7.84[7.29 - 8.44]），血清阳性和血清阴性RA的aHR分别为9.00（8.34 - 9.72）和4.81（4.25 - 5.44）。虽然血清阳性RA中ILD的风险高于血清阴性RA，但血清阴性RA患者发生ILD的风险也高于匹配对照组，这表明应对该人群密切监测ILD。
