[持续性流感病毒感染。持续性感染期间选择的温度敏感突变体的分子遗传特征]
[Persistent influenza virus infection. Molecular genetic characteristics of ts mutants selected during persistence].
作者信息
Medvedeva M N, Medvedeva T E, Aron R A, Iukhnova L G, Simanovskaia V K
出版信息
Vopr Virusol. 1985 Jan-Feb;30(1):46-50.
Properties of ts mutants isolated from systems of persistent influenza infection formed in MDCK cell culture by A/Victoria/35/72 virus were studied. The ts mutants isolated at later intervals of persistent infection (158 days) were characterized by thermolability of hemagglutinin and neuraminidase, changes in the EP mobility of HA2 polypeptide, decrease in the molecular weight of this polypeptide, appearance of multiple ts mutations in genes 3, 5, 6, 7, and 8, coding for P2, NP, NA, M, and NS proteins, respectively.
对从由A/维多利亚/35/72病毒在MDCK细胞培养物中形成的持续性流感感染系统分离出的温度敏感（ts）突变体的特性进行了研究。在持续性感染后期（158天）分离出的ts突变体的特征为血凝素和神经氨酸酶的热不稳定性、HA2多肽的电泳迁移率变化、该多肽分子量降低、分别编码P2、核蛋白（NP）、神经氨酸酶（NA）、基质蛋白（M）和非结构蛋白（NS）的基因3、5、6、7和8中出现多个ts突变。
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