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低剂量电离辐射与暴露延迟反应：重庆职业辐射工作者健康影响前瞻性队列研究方案

Low-dose ionizing radiation and the exposure-lag response: protocol for a prospective cohort study on The Health Effects of Chongqing Occupational Radiation Workers.

作者信息

Qin Xiao-Ling, Huang Qiang, Zhang Han-Wen, Zeng Yi, Lin Xian-Shu, Fan Xiao-Yuan, Diao Jun, Chen Cheng-Zhi, Cheng Shu-Qun, Yuan Fang, He Jun-Lin, Li Wei, Xia Yin-Yin

机构信息

School of Public Health, Chongqing Medical University, Chongqing, China.

Chongqing Center for Disease Control and Prevention, Chongqing, China.

出版信息

Front Public Health. 2025 Jan 27;13:1531546. doi: 10.3389/fpubh.2025.1531546. eCollection 2025.

DOI:10.3389/fpubh.2025.1531546
PMID:39931302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11808129/
Abstract

INTRODUCTION: Although the effects of ionizing radiation on radiation workers have been extensively studied in China, no prospective cohort study has been conducted in Chongqing. Furthermore, previous cohorts have not provided a broad-gauge assessment of the temporal relationship between low-dose occupational radiation exposure and the risk of health outcomes. METHODS: A prospective cohort study will be carried out focusing on radiation workers in Chongqing. Health examination outcomes and radiation dose monitoring data will be collected and analyzed using the distributed lag non-linear model (DLNM) combined with generalized additive model (GAM) or generalized linear model (GLM) to evaluate the exposure-lag response relationship. DISCUSSION: Our study will enhance our understanding of the exposure-lag response association between occupational radiation exposure and the health of radiation workers based on DLNM. CLINICAL TRIAL REGISTRATION: Chinese Clinical Trials Registry, ChiCTR2400081804.

摘要

引言：尽管中国已对电离辐射对放射工作人员的影响进行了广泛研究，但重庆尚未开展前瞻性队列研究。此外，以往的队列研究并未对低剂量职业辐射暴露与健康结果风险之间的时间关系进行全面评估。 方法：将针对重庆的放射工作人员开展一项前瞻性队列研究。收集健康检查结果和辐射剂量监测数据，并使用分布滞后非线性模型（DLNM）结合广义相加模型（GAM）或广义线性模型（GLM）进行分析，以评估暴露-滞后反应关系。 讨论：我们的研究将增进我们基于DLNM对职业辐射暴露与放射工作人员健康之间的暴露-滞后反应关联的理解。 临床试验注册：中国临床试验注册中心，ChiCTR2400081804。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60d/11808129/1fa9323b9046/fpubh-13-1531546-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60d/11808129/4435b4e183cb/fpubh-13-1531546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60d/11808129/5966bbdb6cfc/fpubh-13-1531546-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60d/11808129/1fa9323b9046/fpubh-13-1531546-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60d/11808129/4435b4e183cb/fpubh-13-1531546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60d/11808129/5966bbdb6cfc/fpubh-13-1531546-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60d/11808129/1fa9323b9046/fpubh-13-1531546-g003.jpg

相似文献

[1]
Low-dose ionizing radiation and the exposure-lag response: protocol for a prospective cohort study on The Health Effects of Chongqing Occupational Radiation Workers.

Front Public Health. 2025-1-27

[2]
Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study.

Environ Health Prev Med. 2021-1-25

[3]
Cohort profile: ORICAMs, a French cohort of medical workers exposed to low-dose ionizing radiation.

PLoS One. 2023

[4]
The Relationship Between Occupational Exposure to Low-dose Ionizing Radiation and Changes in Thyroid Hormones in Hospital Workers.

Epidemiology. 2019-7

[5]
Occupational radiation exposure and cancer incidence in a cohort of diagnostic medical radiation workers in South Korea.

Occup Environ Med. 2021-12

[6]
Association between low-dose ionizing radiation and hypertension: a cohort study in China.

Int Arch Occup Environ Health. 2025-3

[7]
Occupational Exposure to Low Dose Ionizing Radiation and the Incidence of Surgically Removed Cataracts and Glaucoma in a Cohort of Ontario Nuclear Power Plant Workers.

Radiat Res. 2025-4-1

[8]
Central nervous system tumours and occupational ionising radiation exposure: a nested case-control study among the ORICAMs cohort of healthcare workers in France.

BMJ Open. 2024-6-19

[9]
Risk of various types of cataracts in a cohort of Mayak workers following chronic occupational exposure to ionizing radiation.

Eur J Epidemiol. 2018-10-10

[10]
Analysis of Hemogram of Radiation Workers in Tangshan, China.

J Clin Lab Anal. 2016-9

本文引用的文献

[1]
Cohort Profile: The Korean Radiation Workers Study (KRWS).

Int J Epidemiol. 2024-4-11

[2]
Trends of occupational exposure to ionizing radiation in Central China for the period 2000-2021.

Appl Radiat Isot. 2024-6

[3]
Cancer mortality after low dose exposure to ionising radiation in workers in France, the United Kingdom, and the United States (INWORKS): cohort study.

BMJ. 2023-8-16

[4]
Chromosomal Aberrations, Micronuclei, Blood Parameters and Received Doses in Workers Exposed to Ionizing Radiation.

Med Lav. 2023-8-2

[5]
Trend and distribution analysis of occupational radiation exposure among medical practices in Chongqing, China (2008-2020).

Radiat Prot Dosimetry. 2023-10-18

[6]
Ionizing radiation and solid cancer mortality among US nuclear facility workers.

Int J Epidemiol. 2023-8-2

[7]
Cancer Incidence in Korean Healthcare Workers in Hospitals.

Cancers (Basel). 2023-3-29

[8]
Increased cardiovascular disease risk after exposure to low dose radiation.

BMJ. 2023-3-8

[9]
Iodine nutrition level and thyroid function in pregnant women in the Yongchuan district of Chongqing.

J Clin Transl Res. 2022-11-10

[10]
Cumulative effects of temperature on blood pressure during pregnancy: A cohort study of differing effects in three trimesters.

Sci Total Environ. 2023-2-10

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