Regidor Pedro Antonio, Eiblwieser Johanna, Steeb Theresa, Rizo Jose Miguel
Medical Department, Exeltis Healthcare, Ismaning, 85737, Germany.
Medical Department, Exeltis Germany, Ismaning, Adalperostr. 84, 85737, Germany.
F1000Res. 2024 Dec 23;13:882. doi: 10.12688/f1000research.153569.2. eCollection 2024.
Preterm birth is a major cause of perinatal complications and neonatal deaths. Furthermore, in the field of obstetrics many clinical entities like uterine contractions or the occurrence of pre- eclampsia remain to be serious complications during pregnancy and represent a major psychological, financial, and economic burden for society. Several published guidelines, studies and recommendations have highlighted the importance of supplementation of omega-3 long chain polyunsaturated fatty acids (PUFAs) during pregnancy. This narrative review aims at giving an overview on the modern perception of inflammatory processes and the role of specialized pro-resolving mediators (SPMs) in their resolution, especially in obstetrics. Additionally, we highlight the possible role of SPMs in the prevention of obstetric complications through oral supplementation using enriched marine oil nutritional's. The intake of PUFAs may result in an overall improvement of pregnancy outcomes by contributing to fetal brain growth and neurological development but more importantly though modulation of inflammation-associated pathologies. Especially the use of SPMs represents a promising approach for the management of obstetric and perinatal complications. SPMs are monohydroxylates derived from enriched marine oil nutritional's that involve certain pro-resolutive metabolites of omega-3 long chains PUFAs and may contribute to an attenuation of inflammatory diseases. This may be obtained through various mechanisms necessary for a proper resolution of inflammation such as the termination of neutrophil tissue infiltration, initiation of phagocytosis, downregulation of pro-inflammatory cytokines or tissue regeneration. In this way, acute and chronic inflammatory diseases associated with serious obstetrical complications can be modulated, which might contribute to an improved pregnancy outcome.
早产是围产期并发症和新生儿死亡的主要原因。此外，在产科领域，许多临床情况，如子宫收缩或先兆子痫的发生，仍然是妊娠期间的严重并发症，对社会造成了重大的心理、财政和经济负担。一些已发表的指南、研究和建议强调了孕期补充ω-3长链多不饱和脂肪酸（PUFAs）的重要性。本叙述性综述旨在概述对炎症过程的现代认识以及专门的促解决介质（SPMs）在其消退过程中的作用，特别是在产科领域。此外，我们强调了通过口服富含海洋油营养剂补充SPMs在预防产科并发症方面的可能作用。摄入PUFAs可能通过促进胎儿大脑生长和神经发育，更重要的是通过调节与炎症相关的病理状况，从而全面改善妊娠结局。特别是使用SPMs是管理产科和围产期并发症的一种有前景的方法。SPMs是源自富含海洋油营养剂的单羟基化产物，涉及ω-3长链PUFAs的某些促消退代谢物，可能有助于减轻炎症性疾病。这可以通过炎症适当消退所需的各种机制来实现，如终止中性粒细胞组织浸润、启动吞噬作用、下调促炎细胞因子或组织再生。通过这种方式，可以调节与严重产科并发症相关的急性和慢性炎症性疾病，这可能有助于改善妊娠结局。
