Sui Haijing, Luo Zhu, Zhang Xuehan, Zhang Junbo, Zhen Zhen, Ding Ting
Department of Otolaryngology, Head and Neck Surgery, Peking University First Hospital, Beijing, China.
Department of Otolaryngology for Children, Mianyang Maternal and Child Healthcare Hospital (Mianyang Children's Hospital), Mianyang, China.
Acta Otolaryngol. 2025 Apr;145(4):329-333. doi: 10.1080/00016489.2025.2460610. Epub 2025 Feb 11.
Some studies believe that there is a correlation between larygopharyngeal reflux disease (LPRD) and allergic rhinitis (AR). Salivary pepsin concentration (SPC) test is a gradually accepted objective examination method for LPRD in recent years.
To investigate the impact of coexisting LPRD on subjective severity of seasonal AR and the potential role of pepsin.
Adult patients with seasonal AR were prospectively enrolled. Subjective severity of AR was assessed using the Total Nasal Symptom Score (TNSS) and visual analog scale (VAS). Potential LPRD was assessed using the Reflux Symptom Index (RSI) and SPC measurements.
No significant correlation was found between the RSI value and the TNSS and VAS values (both > .05). In contrast, the SPC value was found to be significantly associated with both of TNSS and VAS values ( < .05). Among the symptoms included in the TNSS, the SPC value was significantly and positively associated with nasal congestion and runny nose (both < .05), but not with sneezing and nasal itching (both > .05).
Coexisting LPRD may aggravates seasonal AR symptoms. SPC could be used to examine whether AR patients have combined LPRD and to determine the necessity of anti-reflux treatment.
一些研究认为喉咽反流病（LPRD）与变应性鼻炎（AR）之间存在关联。唾液胃蛋白酶浓度（SPC）检测是近年来逐渐被认可的一种用于LPRD的客观检查方法。
探讨并存的LPRD对季节性AR主观严重程度的影响以及胃蛋白酶的潜在作用。
前瞻性纳入成年季节性AR患者。使用总鼻症状评分（TNSS）和视觉模拟量表（VAS）评估AR的主观严重程度。使用反流症状指数（RSI）和SPC测量评估潜在的LPRD。
未发现RSI值与TNSS和VAS值之间存在显著相关性（均>0.05）。相比之下，发现SPC值与TNSS和VAS值均显著相关（<0.05）。在TNSS所包含的症状中，SPC值与鼻塞和流涕显著正相关（均<0.05），但与打喷嚏和鼻痒无关（均>0.05）。
并存的LPRD可能会加重季节性AR症状。SPC可用于检查AR患者是否合并LPRD，并确定抗反流治疗的必要性。
