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[临床与实验性肌萎缩性白质海绵状变性(进行性脊髓性肌萎缩)]

[Clinical and experimental amyotrophic leukospongiosis (progressive spinal amyotrophy)].

作者信息

Votiakov V I, Protas I I, Nedz'ved' M K, Rytik P G, Antonov I P

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(3):330-3.

PMID:3993291
Abstract

The authors succeeded in reproducing amyotrophic leukospongiosis in experiments on two squirrel monkeys 16-23 months after challenge with cerebral suspension obtained at autopsy from a human patient. The clinico-morphological studies showed the similarity of the disease in humans and monkeys. A previously unknown agent belonging by its properties to "slow" viruses was isolated. The successful reproduction of amyotrophic leukospongiosis under experimental conditions proved its infectious nature.

摘要

作者们在对两只松鼠猴进行实验时成功再现了肌萎缩性白质海绵状脑病。实验是在用从一名人类患者尸检获得的脑悬液对松鼠猴进行攻击16 - 23个月后进行的。临床形态学研究表明了人类和猴子身上该疾病的相似性。分离出了一种性质上属于“慢”病毒的此前未知的病原体。在实验条件下肌萎缩性白质海绵状脑病的成功再现证明了其传染性本质。

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