Urtti A, Salminen L
Acta Ophthalmol (Copenh). 1985 Feb;63(1):16-8. doi: 10.1111/j.1755-3768.1985.tb05207.x.
Topical unilateral application of timolol reduces the IOP (intraocular pressure) of both the treated and the untreated eye. For this reason, a cental mechanism of action, in addition to the local one, has been suggested for the reduction of IOP by this drug. In this study timolol concentrations in the iris-ciliary body of the treated and untreated rabbit eyes were compared with pharmacologically active in vitro timolol concentrations. The drug concentration in the untreated eye too was found to be high enough to exert a local action.
局部单侧应用噻吗洛尔可降低治疗眼和未治疗眼的眼压（眼内压）。因此，有人提出该药降低眼压的作用机制除了局部作用外，还有中枢机制。在本研究中，将治疗组和未治疗组兔眼虹膜睫状体中的噻吗洛尔浓度与体外具有药理活性的噻吗洛尔浓度进行了比较。结果发现，未治疗眼中的药物浓度也高到足以发挥局部作用。
