Wei Yuanyuan, Qian He, Zhang Xiaoyu, Wang Jian, Yan Heguo, Xiao Niqin, Zeng Sanjin, Chen Bingbing, Yang Qianqian, Lu Hongting, Xie Jing, Xie Zhaohu, Qin Dongdong, Li Zhaofu
First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, China.
School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, Yunnan, China.
Biomark Res. 2025 Feb 11;13(1):26. doi: 10.1186/s40364-025-00732-y.
Osteoarthritis (OA), a ubiquitous degenerative joint disorder, is marked by pain and disability, profoundly impacting patients' quality of life. As the population ages, the global prevalence of OA is escalating. Omics technologies have become instrumental in investigating complex diseases like OA, offering comprehensive insights into its pathogenesis and progression by uncovering disease-specific alterations across genomics, transcriptomics, proteomics, and metabolomics levels. In this review, we systematically analyzed and summarized the application and recent achievements of omics technologies in OA research by scouring relevant literature in databases such as PubMed. These studies have shed light on new potential therapeutic targets and biomarkers, charting fresh avenues for OA diagnosis and treatment. Furthermore, in our discussion, we highlighted the immense potential of spatial omics technologies in unraveling the molecular mechanisms of OA and in the development of novel therapeutic strategies, proposing future research directions and challenges. Collectively, this study encapsulates the pivotal advances in current OA research and prospects for future investigation, providing invaluable references for a deeper understanding and treatment of OA. This review aims to synthesize the recent progress of omics technologies in the realm of OA, aspiring to furnish theoretical foundations and research orientations for more profound studies of OA in the future.
骨关节炎（OA）是一种常见的退行性关节疾病，以疼痛和功能障碍为特征，对患者的生活质量产生深远影响。随着人口老龄化，OA的全球患病率正在上升。组学技术已成为研究OA等复杂疾病的重要工具，通过揭示基因组学、转录组学、蛋白质组学和代谢组学水平上的疾病特异性改变，为其发病机制和进展提供全面见解。在本综述中，我们通过检索PubMed等数据库中的相关文献，系统分析和总结了组学技术在OA研究中的应用和最新成果。这些研究揭示了新的潜在治疗靶点和生物标志物，为OA的诊断和治疗开辟了新途径。此外，在讨论中，我们强调了空间组学技术在揭示OA分子机制和开发新治疗策略方面的巨大潜力，提出了未来的研究方向和挑战。总的来说，本研究概括了当前OA研究的关键进展和未来研究前景，为更深入理解和治疗OA提供了宝贵参考。本综述旨在综合组学技术在OA领域的最新进展，为未来更深入研究OA提供理论基础和研究方向。
