Pretibial myxedema is a localized dermopathy seen in patients with past or present hyperthyroidism. Massive intradermal deposition of mucin (acid mucopolysaccharide) produces the classic indurated nodules or plaques on the anterior lower legs. Most patients have elevated levels of LATS in their serum; however, this appears to be a marker for the disease, rather than a cause. Mild pretibial myxedema requires no treatment. Topical, intralesional or systemic steroids may be useful in severe cases.
胫前黏液性水肿是一种见于既往或目前患有甲状腺功能亢进症患者的局限性皮肤病。黏蛋白（酸性黏多糖）在真皮内大量沉积，在前小腿产生典型的硬结性结节或斑块。大多数患者血清中长效甲状腺刺激素（LATS）水平升高；然而，这似乎是该疾病的一个标志物，而非病因。轻度胫前黏液性水肿无需治疗。严重病例中，外用、皮损内注射或全身应用类固醇可能有效。
