Murray J J, Heim C R
Am J Med. 1985 May;78(5):881-4. doi: 10.1016/0002-9343(85)90300-6.
Hypercalcemia associated with disseminated histoplasmosis in an elderly male is described. Serum calcium levels increased during vitamin D supplementation, supporting the proposed mechanism of hypercalcemia in granulomatous diseases. Rapid clinical deterioration and death occurred shortly after administration of steroids for relative adrenal insufficiency. Vitamin D and calcium supplements may aggravate the hypercalcemia of granulomatous disease and should be avoided.
本文描述了一名老年男性因播散性组织胞浆菌病伴发高钙血症的病例。补充维生素D期间血清钙水平升高，支持了肉芽肿性疾病中高钙血症的推测机制。在因相对肾上腺功能不全给予类固醇治疗后不久，患者出现快速临床恶化并死亡。维生素D和钙补充剂可能会加重肉芽肿性疾病的高钙血症，应避免使用。
