Forbes Malcolm, Lotfaliany Mojtaba, Tran Cammie, Mohebbi Mohammadreza, Woods Robyn L, McNeil John J, Berk Michael
The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
J Gerontol A Biol Sci Med Sci. 2025 May 5;80(6). doi: 10.1093/gerona/glaf019.
Testosterone has been implicated in mood regulation, yet its role in the development and treatment of depression remains unclear. This study investigated the association between testosterone concentrations and the incidence of depression in older men.
We utilized data from 4 107 men aged 70 years and older who participated in the Aspirin in Reducing Events in the Elderly (ASPREE) and ASPREE-XT studies. Serum total testosterone concentrations were measured at baseline and year 3. Depressive symptoms were assessed annually using the CES-D-10 scale, with incident depression defined as a CES-D-10 score of ≥8. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) for incident depression, adjusted for potential confounders.
During a median follow-up of 8.4 years, 1 449 participants experienced an episode of depression. Baseline total testosterone concentrations were not significantly associated with the risk of incident depression, whether treated as continuous variables (HR 1.00, 95% CI 0.99-1.01) or when categorized into quintiles. Similarly, changes in testosterone concentrations from baseline to year 3 did not predict incident depression (aHR 1.03, 95% CI 0.99-1.08). A subgroup analysis focusing on men with biochemical evidence of hypogonadism also found no association with incident depression.
Our findings do not support an association between testosterone concentrations and the risk of developing depression in older men. These results suggest that testosterone is not an important factor in the pathogenesis of depression in this population. There may still be individual variability in response to testosterone changes and its potential impact on mood disorders.
睾酮与情绪调节有关，但其在抑郁症发生和治疗中的作用仍不明确。本研究调查了老年男性睾酮浓度与抑郁症发病率之间的关联。
我们利用了4107名70岁及以上男性的数据，这些男性参与了老年人阿司匹林减少事件（ASPREE）和ASPREE-XT研究。在基线和第3年测量血清总睾酮浓度。每年使用CES-D-10量表评估抑郁症状，将新发抑郁症定义为CES-D-10评分≥8。使用Cox比例风险回归模型估计新发抑郁症的风险比（HR），并对潜在混杂因素进行调整。
在中位随访8.4年期间，1449名参与者经历了一次抑郁发作。基线总睾酮浓度与新发抑郁症风险无显著关联，无论是作为连续变量处理（HR 1.00，95%CI 0.99-1.01）还是分为五分位数时。同样，从基线到第3年睾酮浓度的变化也不能预测新发抑郁症（校正后HR 1.03，95%CI 0.99-1.08）。一项针对有性腺功能减退生化证据男性的亚组分析也未发现与新发抑郁症有关联。
我们的研究结果不支持睾酮浓度与老年男性患抑郁症风险之间存在关联。这些结果表明，睾酮不是该人群抑郁症发病机制中的重要因素。对睾酮变化及其对情绪障碍潜在影响的反应可能仍存在个体差异。
