Field M
Rev Infect Dis. 1979 Nov-Dec;1(6):918-26. doi: 10.1093/clinids/1.6.918.
Current information on the intestinal secretory mechanism and on the actions of the enterotoxins from Vibrio cholerae and Escherichia coli are reviewed. These enterotoxins, through their effects on the metabolism of cyclic nucleotides, both inhibit active absorption and stimulate active secretion of water and electrolytes in the small intestine. the enterotoxin of V. chol erae and the heat-labile enterotoxin of E. coli affect these activities by stimulating adenylate cyclase, and the heat-stable enterotoxin of E. coli does so by stimulating guanylate cyclase.
本文综述了关于肠道分泌机制以及霍乱弧菌和大肠杆菌肠毒素作用的最新信息。这些肠毒素通过影响环核苷酸代谢，既抑制小肠中水分和电解质的主动吸收，又刺激其主动分泌。霍乱弧菌肠毒素和大肠杆菌不耐热肠毒素通过刺激腺苷酸环化酶来影响这些活动，而大肠杆菌耐热肠毒素则通过刺激鸟苷酸环化酶来实现。
