Wang Lei, Zhou Wen
Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China; Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Immunity. 2025 Feb 11;58(2):265-267. doi: 10.1016/j.immuni.2025.01.012.
Renowned for driving interferon responses, the cGAS-STING pathway reveals a surprising role: lysosomal biogenesis. In this issue of Immunity, Xu et al. uncover how STING activates the transcription factor TFEB, linking innate immune sensing to enhanced pathogen clearance through lysosomal activity.
cGAS-STING通路以驱动干扰素反应而闻名，它还揭示了一个惊人的作用：溶酶体生物发生。在本期《免疫》杂志中，徐等人揭示了STING如何激活转录因子TFEB，将先天免疫感知与通过溶酶体活性增强病原体清除联系起来。
