Ziar Rania, Tesar Paul J, Clayton Benjamin L L
Institute for Glial Sciences, Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Institute for Glial Sciences, Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Neurotherapeutics. 2025 Apr;22(3):e00540. doi: 10.1016/j.neurot.2025.e00540. Epub 2025 Feb 11.
Astrocytes and oligodendrocytes, once considered passive support cells, are now recognized as active participants in the pathogenesis of Alzheimer's disease. Emerging evidence highlights the critical role that these glial cells play in the pathological features of Alzheimer's, including neuroinflammation, excitotoxicity, synaptic dysfunction, and myelin degeneration, which contribute to neurodegeneration and cognitive decline. Here, we review the current understanding of astrocyte and oligodendrocyte pathology in Alzheimer's disease and highlight research that supports the therapeutic potential of modulating astrocyte and oligodendrocyte functions to treat Alzheimer's disease.
星形胶质细胞和少突胶质细胞，曾经被认为是被动的支持细胞，现在被公认为是阿尔茨海默病发病机制中的积极参与者。新出现的证据突出了这些神经胶质细胞在阿尔茨海默病病理特征中所起的关键作用，包括神经炎症、兴奋性毒性、突触功能障碍和髓鞘变性，这些都导致了神经退行性变和认知能力下降。在此，我们综述了目前对阿尔茨海默病中星形胶质细胞和少突胶质细胞病理的理解，并强调了支持调节星形胶质细胞和少突胶质细胞功能以治疗阿尔茨海默病的治疗潜力的研究。
