Alfaro-Magallanes V M, Medrano M, Echarte J, Osés M, Izquierdo C, De Caridad-Concepción M, Galbete A, Idoate F, Zugasti A, Petrina M E, Goñi E, Ribelles M J, Amasene M, Arenaza L, Tejada C, Elejalde E, Azcarate U, Ruiz-Sarrias O, Sayar-Beristain O, García-Ramos A, Martínez-Labari C, Armendariz-Brugos C, Villanueva A, Ruiz J R, Cabeza R, Labayen I
Institute for Sustainability & Food Chain Innovation, Department of Health Sciences, Public University of Navarre, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; LFE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, Madrid, Spain.
Institute for Sustainability & Food Chain Innovation, Department of Health Sciences, Public University of Navarre, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Nutr Metab Cardiovasc Dis. 2025 May;35(5):103844. doi: 10.1016/j.numecd.2024.103844. Epub 2024 Dec 30.
BACKGROUND & AIMS: Time-restricted eating (TRE) shows promise for weight loss and improving menopause-related body composition and cardiometabolic health, but its effects on skeletal muscle tissue (SMT) in postmenopausal women are unknown. This study investigates the effects of three weight loss interventions over 12 weeks on SMT quantity, quality, function, and cardiometabolic health in postmenopausal women with overweight/obesity, with effects persistence evaluated at a 12-month follow-up.
In this randomized controlled trial, 78 postmenopausal women (50-65 years; BMI 25-40 kg/m; sedentary lifestyle; eating window ≥12 h/day; no severe metabolic impairments) will be recruited. Participants will be randomly assigned to one of three groups for 12 weeks: TRE, TRE + resistance training, or CR + resistance training. The TRE groups will reduce their eating window to 8 h and receive nutritional advice to adhere to a Mediterranean diet. The CR group will follow a personalized hypocaloric diet (-500 kcal/day). Resistance training groups will perform supervised resistance training 3 times/week.
Change in SMT quantity measured by MRI at baseline and after 12 weeks.
intermuscular adipose tissue (IMAT), strength, power, body weight and composition, and cardiometabolic risk factors.
This study will illustrate the effects of TRE and TRE combined with resistance exercise compared with the currently recommended obesity-lifestyle treatment on SMT quantity, quality, function, and cardiometabolic markers. The results will offer insights into dietary strategies to combat obesity and metabolic diseases without increasing sarcopenia risk in postmenopausal women, a sparsely studied and particularly affected population.
限时进食（TRE）在减肥以及改善与更年期相关的身体成分和心脏代谢健康方面显示出前景，但其对绝经后女性骨骼肌组织（SMT）的影响尚不清楚。本研究调查了三种减肥干预措施在12周内对超重/肥胖绝经后女性SMT数量、质量、功能和心脏代谢健康的影响，并在12个月的随访中评估了效果的持续性。
在这项随机对照试验中，将招募78名绝经后女性（50 - 65岁；体重指数25 - 40kg/m²；久坐不动的生活方式；进食窗口≥12小时/天；无严重代谢障碍）。参与者将被随机分配到三组中的一组，为期12周：TRE组、TRE + 阻力训练组或CR + 阻力训练组。TRE组将把进食窗口减少到8小时，并接受遵循地中海饮食的营养建议。CR组将遵循个性化的低热量饮食（每天减少500千卡）。阻力训练组将每周进行3次有监督的阻力训练。
通过MRI在基线和12周后测量的SMT数量变化。
肌间脂肪组织（IMAT）、力量、功率、体重和身体成分，以及心脏代谢危险因素。
本研究将阐明与目前推荐的肥胖生活方式治疗相比，TRE以及TRE与阻力运动相结合对SMT数量、质量、功能和心脏代谢标志物的影响。研究结果将为在不增加绝经后女性肌肉减少症风险的情况下对抗肥胖和代谢疾病的饮食策略提供见解，这一人群研究较少且受影响尤为严重。
