Cheng Jufang, Bu Chaozhi, Zheng Xiaowei
Department of Neonatology, Wuxi Children's Hospital, Wuxi School of Medicine, Affiliated Children's Hospital of Jiangnan University, Jiangnan University, Wuxi, China.
Research Institute for Reproductive Health and Genetic Diseases, Wuxi School of Medicine, Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi, 214002, China.
Sci Rep. 2025 Feb 12;15(1):5260. doi: 10.1038/s41598-025-89569-x.
Previous studies have reported that cardiorespiratory fitness (CRF) was associated with decreased risk of chronic kidney disease (CKD) in westerner. The aim of present study was to investigate the potential association between estimated eCRF (eCRF) and CKD risk in Chinese general population. A total of 5,199 participants from the China Health and Retirement Longitudinal Study were including in analysis. The sex-specific models including age, physical activity, resting heart rate, and waist circumference were used to calculate eCRF. Participants were divided into three subgroups according to age and sex-specific tertiles of eCRF. Cox proportional hazards regression models were used to examine the associations between eCRF and CKD. During 9 years of follow-up, a total of 511 respondents experienced CKD. After adjustment for potential variables, the hazard ratio (95% confidence intervals) for the tertile 2 and tertile 3 of eCRF was 0.80 (0.66-0.96) and 0.74 (0.60-0.92), respectively, compared with the lowest tertiles. Moreover, each 1-SD increase of eCRF was associated with 6% (95%CIs, 1-11%) decreased risk of CKD. Similar associations were also found in both male and female subgroups. When the current study calculated eCRF using body mass index instead of waist circumference, the highest tertiles of eCRF was significantly associated with decreased risk of CKD in overall and female participants. A higher eCRF was associated with a decreased risk of CKD in general Chinese population. Future well-designed prospective clinical studies are needed to verify our findings and to assess the effect of eCRF interventions in CKD prevention.
先前的研究报道，在西方人中，心肺适能（CRF）与慢性肾脏病（CKD）风险降低相关。本研究的目的是调查中国普通人群中估算的心肺适能（eCRF）与CKD风险之间的潜在关联。来自中国健康与养老追踪调查的5199名参与者纳入分析。使用包含年龄、身体活动、静息心率和腰围的性别特异性模型来计算eCRF。参与者根据年龄和eCRF的性别特异性三分位数分为三个亚组。采用Cox比例风险回归模型来检验eCRF与CKD之间的关联。在9年的随访期间，共有511名受访者发生CKD。在对潜在变量进行调整后，与最低三分位数相比，eCRF的第二三分位数和第三三分位数的风险比（95%置信区间）分别为0.80（0.66 - 0.96）和0.74（0.60 - 0.92）。此外，eCRF每增加1个标准差，CKD风险降低6%（95%置信区间，1% - 11%）。在男性和女性亚组中也发现了类似的关联。当本研究使用体重指数而非腰围来计算eCRF时，eCRF的最高三分位数与总体和女性参与者中CKD风险降低显著相关。较高的eCRF与中国普通人群中CKD风险降低相关。未来需要设计良好的前瞻性临床研究来验证我们的发现，并评估eCRF干预在CKD预防中的效果。
