Lee Clement, Park David, Shiu Wai-Tung, Liu Yihong, Liu Lijia
Department of Chemistry, Western University, 1151 Richmond Street, London, ON N6A 5B7, Canada.
Nanomaterials (Basel). 2025 Feb 6;15(3):247. doi: 10.3390/nano15030247.
Near-infrared persistent luminescence (PersL) nanoparticles (NPs) have great potential in biomedical applications due to their ability to continuously emit tissue-penetrating light. Despite numerous reports on the distribution, biological safety and other consequences of PersL NPs in vitro and in vivo, there has been a lack of studies on the optical properties of these NPs in the physiological environment. In light of this, we investigated the effects of short-term immersion of the prominent Cr-doped ZnGaO (CZGO) NPs in a simulated physiological environment for up to 48 h. This paper reports the changes in the structural and optical properties of CZGO NPs after their immersion in a phosphate-buffered saline (PBS) solution for pre-determined time intervals. Interestingly, the luminescence intensity and lifetime noticeably improved upon exposure to the PBS media, which is unusual among existing nanomaterials explored as bioimaging probes. After 48 h of immersion in the PBS solution, the CZGO NPs were approximately twice as bright as the non-immersed sample. X-ray spectroscopic techniques revealed the formation of ZnO, which results in an improvement in observed luminescence.
近红外持续发光（PersL）纳米颗粒（NPs）因其能够持续发射穿透组织的光而在生物医学应用中具有巨大潜力。尽管有大量关于PersL NPs在体外和体内的分布、生物安全性及其他影响的报道，但在生理环境中对这些NPs光学性质的研究却很缺乏。鉴于此，我们研究了著名的掺铬ZnGaO（CZGO）NPs在模拟生理环境中短期浸泡长达48小时的影响。本文报道了CZGO NPs在磷酸盐缓冲盐水（PBS）溶液中浸泡预定时间间隔后其结构和光学性质的变化。有趣的是，暴露于PBS介质后，发光强度和寿命显著提高，这在作为生物成像探针探索的现有纳米材料中并不常见。在PBS溶液中浸泡48小时后，CZGO NPs的亮度约为未浸泡样品的两倍。X射线光谱技术揭示了ZnO的形成，这导致观察到的发光有所改善。
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