Sokou Rozeta, Bikouli Efstathia-Danai, Tsantes Andreas G, Halvatsiotis Panagiotis, Houhoula Dimitra, Taliaka Kopanou Paschalia, Liakou Paraskevi, Tavoulari Evangelia-Filothei, Piovani Daniele, Bonovas Stefanos, Iliodromiti Zoi, Boutsikou Theodora, Iacovidou Nicoletta, Theodoraki Martha, Tsantes Argirios E
Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Neonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, 18454 Piraeus, Greece.
Int J Mol Sci. 2025 Jan 30;26(3):1201. doi: 10.3390/ijms26031201.
The COVID-19 pandemic has raised significant concerns regarding its potential impact on maternal and neonatal health. This study aimed to investigate the immunologic and hemostatic profiles of neonates exposed to SARS-CoV-2 during the peripartum period (0-14 days prior to delivery). This retrospective study included 28 neonates born to COVID-19-positive mothers during the peripartum period and a control group of 54 neonates born to mothers who never tested positive for SARS-CoV-2 during pregnancy. Arterial blood samples were collected from all neonates on the second day of life for the simultaneous assessment of full blood count, C-reactive protein (CRP), serum interleukin-6 (IL-6), and Interferon gamma-induced protein 10 (IP-10) levels, as well as Rotational Thromboelastometry (ROTEM) tests (EXTEM, INTEM, and NATEM). Neonates born to COVID-19-positive mothers and those born to COVID-19-negative mothers exhibited similar coagulation profiles based on ROTEM analysis. Multiple linear regression analysis revealed that peripartum COVID-19 infection was associated with higher IP-10 levels in neonates (coefficient: +16.8, 95% CI: +9.0 to +24.6, < 0.0001). Our study findings suggest that the presence of immunologic disturbance in neonates is related to recent peripartum exposure to maternal SARS-CoV-2 infection, as evidenced by increased IP-10 levels in blood samples obtained from neonates born to SARS-CoV-2-positive mothers. However, peripartum exposure to maternal SARS-CoV-2 did not appear to disrupt the hemostatic profile of the exposed newborns based on ROTEM test results.
新冠疫情引发了人们对其对孕产妇和新生儿健康潜在影响的重大担忧。本研究旨在调查在围产期（分娩前0 - 14天）接触过新冠病毒的新生儿的免疫和止血情况。这项回顾性研究纳入了28名在围产期出生于新冠病毒检测呈阳性母亲的新生儿，以及一个对照组，该对照组由54名出生于孕期新冠病毒检测从未呈阳性母亲的新生儿组成。在出生第二天从所有新生儿采集动脉血样本，以同时评估全血细胞计数、C反应蛋白（CRP）、血清白细胞介素 - 6（IL - 6）、干扰素γ诱导蛋白10（IP - 10）水平，以及旋转血栓弹力图（ROTEM）检测（EXTEM、INTEM和NATEM）。基于ROTEM分析，出生于新冠病毒检测呈阳性母亲的新生儿和出生于新冠病毒检测呈阴性母亲的新生儿表现出相似的凝血情况。多元线性回归分析显示，围产期新冠病毒感染与新生儿较高的IP - 10水平相关（系数： + 16.8，95%置信区间： + 9.0至 + 24.6， < 0.0001）。我们的研究结果表明，新生儿免疫紊乱的存在与围产期近期接触母体新冠病毒感染有关，这一点可通过从新冠病毒检测呈阳性母亲所生新生儿采集的血样中IP - 10水平升高得到证明。然而，基于ROTEM检测结果，围产期接触母体新冠病毒似乎并未破坏受影响新生儿的止血情况。
