Wójtowicz Kamila, Kot Justyna, Makara-Studzińska Marta, Wdowiak Natalia, Filip Michał, Wróbel Andrzej, Wróbel Jan, Matuszyk Dorota, Bojar Melania, Bartosińska Joanna, Wdowiak Artur
Medical Center Łańcut Gynecology and Obstetrics Department, 37-100 Łańcut, Poland.
Faculty of Health Sciences, Jagiellonian University Medical College, 31-126 Kraków, Poland.
J Clin Med. 2025 Jan 23;14(3):721. doi: 10.3390/jcm14030721.
Infertile people experience a lot of psychological stress due to the inability to conceive and achieve pregnancy. Studies on the quality of life (QoL) of people undergoing infertility treatment typically show a lower QoL for couples struggling with reproductive problems. In recent years, a new factor that may have had a stressful impact on people treated for infertility is the COVID-19 pandemic. The aim of this study is to assess the impact of the COVID-19 pandemic on the QoL of Polish women treated for infertility and on the secretion of selected sex hormones. The study sample consisted of 600 women undergoing treatment due to infertility and 100 healthy women in a control group. The World Health Organization Quality of Life-BREF (WHOQOL-BREF) and the Polish version of the questionnaire Fertility Quality of Life (FertiQoL) were used for data collection. The levels of selected hormones were measured from blood samples. The effects of the pandemic were visible primarily in the reduced QoL of patients. The QoL in terms of physical health, psychological health, social relationships, and environmental sphere was drastically reduced by COVID-19, especially among women treated with IVF (in vitro fertilization) and IUI (intrauterine insemination). The hormonal status of women treated for infertility during the pandemic significantly changed due to a decrease in FSH (follicle-stimulating hormone) and LH (luteinizing hormone) secretion and an increase in PRL (prolactin). The pandemic resulted in a decline in the QoL of women with reproductive problems. The quality of life was influenced by the type of therapy used during infertility treatment. The study also suggests a relationship between a decrease in the quality of life of persons treated for infertility during the pandemic and their hormonal status.
不孕不育的人由于无法受孕和实现妊娠而经历大量心理压力。关于接受不孕不育治疗人群生活质量（QoL）的研究通常表明，在生殖问题上挣扎的夫妇生活质量较低。近年来，一个可能对接受不孕不育治疗的人产生压力影响的新因素是新冠疫情。本研究的目的是评估新冠疫情对接受不孕不育治疗的波兰女性生活质量以及所选性激素分泌的影响。研究样本包括600名因不孕不育接受治疗的女性和100名作为对照组的健康女性。使用世界卫生组织生活质量简表（WHOQOL - BREF）和波兰版的生育生活质量问卷（FertiQoL）收集数据。从血样中测量所选激素的水平。疫情的影响主要体现在患者生活质量的下降。新冠疫情使身体健康、心理健康、社会关系和环境领域的生活质量大幅降低，尤其是在接受体外受精（IVF）和宫内人工授精（IUI）治疗的女性中。疫情期间接受不孕不育治疗的女性的激素状态因促卵泡生成素（FSH）和促黄体生成素（LH）分泌减少以及催乳素（PRL）增加而显著改变。疫情导致有生殖问题的女性生活质量下降。生活质量受到不孕不育治疗期间所采用治疗方式的影响。该研究还表明，疫情期间接受不孕不育治疗的人的生活质量下降与其激素状态之间存在关联。
