Paré P D, Brooks L A, Coppin C A, Wright J L, Kennedy S, Dahlby R, Mink S, Hogg J C
Am Rev Respir Dis. 1985 Apr;131(4):521-6. doi: 10.1164/arrd.1985.131.4.521.
Density-dependence of maximal expiratory flow was measured in 110 patients prior to resection for peripheral coin lesions. The resected lung or lobe was examined morphologically and graded for emphysema, membranous bronchiolitis, and respiratory bronchiolitis. Density dependence did not decrease with increasing airway obstruction, and there was no relationship between density-dependence and peripheral airway abnormality or emphysema in the group as a whole. When patients were arbitrarily divided into those with forced expiratory volume in one second (FEV1) greater than 80% predicted (n = 80) and FEV1 less than 80% predicted (n = 30), density-dependence correlated significantly and negatively with membranous bronchiolitis in those with FEV1 greater than 80% predicted and significantly but positively in those with more advanced airway obstruction. We conclude that density-dependence of maximal expiratory flow is not an accurate predictor of peripheral airway abnormality in patients with mild to moderate air-flow obstruction.
对110例因周围型肺结节病变而准备进行切除手术的患者测量了最大呼气流量的密度依赖性。对切除的肺或肺叶进行形态学检查，并对肺气肿、膜性细支气管炎和呼吸性细支气管炎进行分级。密度依赖性并不随气道阻塞的加重而降低，且在整个研究组中，密度依赖性与外周气道异常或肺气肿之间没有关联。当将患者任意分为一秒用力呼气容积（FEV1）大于预测值80%（n = 80）和FEV1小于预测值80%（n = 30）两组时，在FEV1大于预测值80%的患者中，密度依赖性与膜性细支气管炎呈显著负相关，而在气道阻塞更严重的患者中呈显著正相关。我们得出结论，在轻至中度气流阻塞的患者中，最大呼气流量的密度依赖性并非外周气道异常的准确预测指标。
