Teculescu D B, Pham Q T, Hannhart B
Eur J Respir Dis. 1986 Sep;69(3):175-87.
"Sensitive" and "conventional" lung function tests were compared in a group of 114 males, aged 35-55 years, including healthy non-smokers, asymptomatic smokers with normal spirometry, and smokers with chronic bronchitis with or without mild airflow limitation. In non-smokers, with the exception of a MEF vs. FEV1 correlation, "sensitive" and "conventional" tests were independent of each other. In asymptomatic smokers the phase III slope and the closing volume were significantly related to FEV1, RV/TLC and CO transfer factor. In smokers with chronic bronchitis all the "sensitive" tests were related to the "conventional" tests (with the exception of the total lung capacity). Hyperinflation and CO transfer impairment suggest that early emphysema may accompany mucus hypersecretion in smokers.
在一组114名年龄在35至55岁之间的男性中，对“敏感”和“传统”肺功能测试进行了比较，这些男性包括健康的非吸烟者、肺活量测定正常的无症状吸烟者以及患有或未患有轻度气流受限的慢性支气管炎吸烟者。在非吸烟者中，除了最大呼气流量（MEF）与第一秒用力呼气容积（FEV1）的相关性外，“敏感”和“传统”测试相互独立。在无症状吸烟者中，第三相斜率和闭合气量与FEV1、残气量/肺总量（RV/TLC）和一氧化碳弥散量（CO转移因子）显著相关。在患有慢性支气管炎的吸烟者中，所有“敏感”测试均与“传统”测试相关（肺总量除外）。肺过度充气和CO转移受损表明，早期肺气肿可能与吸烟者的黏液分泌过多同时存在。
